Astatine-211 labeling: a study towards automatic production of astatinated antibodies
Artikel i vetenskaplig tidskrift, 2015

Targeted alpha therapy is especially interesting for therapy of microscopic cancer tumors due to short path length and high linear energy transfer of the alpha particles. One of the most promising nuclides for targeted alpha therapy is At-211. To facilitate larger clinical studies using At-211, the current manual synthesis of radiolabeled antibodies would benefit from being transferred into an automated method. In this work, successful modifications of the manual synthesis have been performed in order to adapt it to automation. The automatic synthesis has also been tested using the modified synthesis method.

CANCER

Chemistry

Chemistry

Nuclear Science &

Inorganic & Nuclear

AT-211-LABELED ANTIBODIES

Radiopharmaceutical module

NUDE-MICE

Immunoconjugates

Antibodies

At-211

ALPHA-RADIOIMMUNOTHERAPY

Analytical

Technology

Labeling

Författare

Emma Aneheim

Göteborgs universitet

Holger Jensen

Per Albertsson

Göteborgs universitet

Sture Lindegren

Göteborgs universitet

Journal of Radioanalytical and Nuclear Chemistry

0236-5731 (ISSN) 1588-2780 (eISSN)

Vol. 303 1 979-983

Ämneskategorier

Radiologi och bildbehandling

DOI

10.1007/s10967-014-3561-8