Reversible Energy-Transfer Switching on a DNA Scaffold
Artikel i vetenskaplig tidskrift, 2015

We show that FRET between Pacific Blue (PB) and Alexa488 (A488) covalently attached to a DNA scaffold can be reversibly controlled by photochromic switching of a spiropyran derivative. With the spiropyran in the closed spiro isomeric form, FRET occurs freely between PB and A488. UV-induced isomerization to the open merocyanine form shuts down the FRET process by efficient quenching of the PB excited state. The process is reversed by exposure to visible light, triggering the isomerization to the spiro isomer.

Författare

Magnus Bälter

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Martin Hammarson

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Patricia Remón Ruiz

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Shiming Li

Chalmers, Kemi och kemiteknik, Kemi och biokemi

N. Gale

University of Southampton

T. Brown

University of Oxford

Joakim Andreasson

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Journal of the American Chemical Society

0002-7863 (ISSN) 1520-5126 (eISSN)

Vol. 137 7 2444-2447

Photochromic Systems for Solid State Molecular Electronic Devices and Light-Activated Cancer Drugs (PHOTOCHROMES)

Europeiska kommissionen (EU) (EC/FP7/203952), 2008-09-01 -- 2013-08-31.

Ämneskategorier

Kemi

DOI

10.1021/ja512416n

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Senast uppdaterat

2022-03-02