Encapsulation of a proteasome inhibitor with gold-polysaccharide nanocarriers
Artikel i vetenskaplig tidskrift, 2014

Organic-inorganic hybrid nanoparticles are potential effective systems for drug delivery in cancer therapy and diagnosis. Chitosan-gum arabic with entrapped gold nanoparticles were developed as a carrier for an anticancer drug bortezomib. The nanosystem was designed to enhance the proteasome inhibitor activity in pancreatic cell lines, S2-013 and hTERT-HPNE. The hydrodynamic diameter of chitosan-gum arabic-gold nanoparticles loaded with bortezomib is around 330 nm. Laser scanning confocal microscopy images show the uptake of the gold nanoparticle/bortezomib encapsulated in chitosan-gum arabic matrix and the fast internalization of these nano combinations into pancreatic cells. Cytotoxic assays assessed that positively charged nanosystems reduce the cell growth and cell proliferation of S2-013s, but the same effect was not observed in cytotoxic response in hTERT-HPNE cells. The outcomes of this study demonstrate the capacity of chitosan-gum arabic nanocarriers to deliver gold nanoparticles/anticancer drug and to increase the permeation and retention effect in S2-013 cells and minimize drug side effects in HPNE cells. © 2014 Springer Science+Business Media.

Cellular uptake

Healthy effects

Cancer cells

Polysaccharides

Gold nanoparticles

Författare

S. C. Coelho

Universidade do Porto

Sandra Rocha

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

P. Sampaio

Instituto de Biologia Molecular e Celular

M. C. Pereira

Universidade do Porto

M. A. N. Coelho

Universidade do Porto

Journal of Nanoparticle Research

1388-0764 (ISSN) 1572-896X (eISSN)

Vol. 16 2368

Ämneskategorier

Nanoteknik

DOI

10.1007/s11051-014-2368-4