Mixing thiols on the surface of silver nanoparticles: Preserving antibacterial properties while introducing SERS activity
Artikel i vetenskaplig tidskrift, 2013

Controlling the surface composition of self-assembled monolayers is one of the major experimental challenges in nanotechnology. Despite the significant interest of the scientific community and the considerable number of publications related to this topic, the potential in this field is still far from being fully exploited. We present in this study a versatile method to coat silver nanoparticles (AgNPs) having average diameter of 7 nm with mixed monolayers of two thiols, achieving a precise control of surface composition. Different combinations of thiols have been investigated, and the nanomaterials obtained have been characterized by complementary experimental techniques, addressing the composition of the mixed monolayer. The surface-enhanced Raman spectroscopy (SERS) effect on a Raman reporter (7-mercapto-4-methylcoumarine) introduced into the mixed monolayers has also been investigated. The antibacterial activity of the coated AgNPs was investigated, showing that the colloids were active against Escherichia coli and Staphilococcus aureus irrespective of the nature of the mixed monolayer. These materials are good candidates as SERS-tags for biological applications. © Springer Science+Business Media 2013.


Silver nanoparticles


Antibacterial activity

Self-assembled monolayers

Mixed monolayers


A. Taglietti

Universita degli studi di Pavia

Yuri Antonio Diaz Fernandez


P. Galinetto

Universita degli studi di Pavia

P. Grisoli

Universita degli studi di Pavia

C. Milanese

Universita degli studi di Pavia

P.S. Pallavicini

Universita degli studi di Pavia

Journal of Nanoparticle Research

1388-0764 (ISSN) 1572-896X (eISSN)

Vol. 15 11 2047




Hållbar utveckling


Nanovetenskap och nanoteknik (SO 2010-2017, EI 2018-)



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