Mind the gap - deficits in our knowledge of aspects impacting bioavailability of phytochemicals and their metabolites - a position paper focusing on carotenoids and polyphenols
Reviewartikel, 2015
Various secondary plant metabolites or phytochemicals, including polyphenols and carotenoids, have been associated with a variety of health benefits, such as reduced incidence of type 2 diabetes, cardiovascular diseases, and several types of cancer, most likely due to their involvement in ameliorating inflammatory and oxidative stress. However, discrepancies exist between their putative effects when comparing observational and intervention studies, especially when using pure compounds. These discrepancies may in part be explained by differences in intake levels and their bioavailability. Prior to exerting their bioactivity, these compounds must be made bioavailable, and considerable differences may arise due to their their matrix release, changes during digestion, uptake, metabolism, and biodistribution, even before considering dose and host related factors. Though many insights have been gained on factors affecting secondary plant metabolite bioavailability, many gaps still exist in our knowledge. In this position paper, we highlight several major gaps in our understanding of phytochemical bioavailability, including effects of food processing, changes during digestion, involvement of cellular transporters in influx/efflux through the gastrointestinal epithelium, changes during colonic fermentation, and their phase I and phase II metabolism following absorption.
Microbiota
Food processing
Mixed diet
Biotransformation
Transporters
Författare
T. Bohn
Luxembourg Institute of Science and Technology
Gordon J. McDougall
The James Hutton Institute
Amparo Alegria
Universitat de Valencia
Marie Alminger
Chalmers, Biologi och bioteknik, Livsmedelsvetenskap
Eva Arrigoni
Forschungsanstalt Agroscope Changins-Wadenswil
Anna-Marja Aura
Teknologian Tutkimuskeskus (VTT)
Catarina Brito
Instituto de Biologia Experimental e Tecnologica
Universidade NOVA de Lisboa
Antonio Cilla
Universitat de Valencia
Sedef N. El
Ege Universitesi
S. Karakaya
Ege Universitesi
Marie C. Martinez-Cuesta
Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM)
C. N. Santos
Instituto de Biologia Experimental e Tecnologica
Universidade NOVA de Lisboa
Molecular Nutrition and Food Research
16134125 (ISSN) 16134133 (eISSN)
Vol. 59 7 1307-13231-17-1323Ämneskategorier
Annan teknik
Biokemi och molekylärbiologi
Annan kemi
Näringslära
Fundament
Grundläggande vetenskaper
Styrkeområden
Livsvetenskaper och teknik (2010-2018)
DOI
10.1002/mnfr.201400745