Genome scale models of yeast: towards standardized evaluation and consistent omic integration
Artikel i vetenskaplig tidskrift, 2015

Genome scale models (GEMs) have enabled remarkable advances in systems biology, acting as functional databases of metabolism, and as scaffolds for the contextualization of high-throughput data. In the case of Saccharomyces cerevisiae (budding yeast), several GEMs have been published and are currently used for metabolic engineering and elucidating biological interactions. Here we review the history of yeast's GEMs, focusing on recent developments. We study how these models are typically evaluated, using both descriptive and predictive metrics. Additionally, we analyze the different ways in which all levels of omics data (from gene expression to flux) have been integrated in yeast GEMs. Relevant conclusions and current challenges for both GEM evaluation and omic integration are highlighted.

Författare

Benjamin José Sanchez Barja

Chalmers, Biologi och bioteknik, Systembiologi

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Integrative Biology (United Kingdom)

1757-9694 (ISSN) 1757-9708 (eISSN)

Vol. 7 8 846-858

Ämneskategorier

Biologiska vetenskaper

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1039/C5IB00083A

PubMed

26079294

Mer information

Skapat

2017-10-08