Biological activity and molecular structures of bis(benzimidazole) and trithiocyanurate complexes
Artikel i vetenskaplig tidskrift, 2015

1-(1H-Benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methanamine (abb) and 2-(1H-benzimidazol-2-ylmethylsulfanylmethyl)-1H-benzimidazole (tbb) have been prepared and characterized by elemental analysis. These bis(benzimidazoles) have been further used in combination with trithiocyanuric acid for the preparation of complexes. The crystal and molecular structures of two of them have been solved. Each nickel atom in the structure of trinuclear complex [Ni 3 (abb) 3 (H 2 O) 3 (μ-ttc)](ClO 4 ) 3 •3H 2 O•EtOH (1), where ttcH3 = trithiocyanuric acid, is coordinated with three N atoms of abb, the N,S donor set of ttc anion and an oxygen of a water molecule. The crystal of [(tbbH 2 )(ttcH 2 ) 2 (ttcH 3 )(H 2 O)] (2) is composed of a protonated bis(benzimidazole), two ttcH 2 anions, ttcH3 and water. The structure is stabilized by a network of hydrogen bonds. These compounds were primarily synthesized for their potential antimicrobial activity and hence their possible use in the treatment of infections caused by bacteria or yeasts (fungi). The antimicrobial and antifungal activity of the prepared compounds have been evaluated on a wide spectrum of bacterial and yeast strains and clinical specimens isolated from patients with infectious wounds and the best antimicrobial properties were observed in strains after the use of ligand abb and complex 1, when at least 80% growth inhibition was achieved.

Trimercaptotriazine

Single crystal X-ray diffraction

Trithiocyanuric acid

Coordination compounds

Biological activity

Benzimidazole

Författare

Pavel Kopel

Mendelova univerzita v Brne

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

D. Wawrzak

Akademia im. Jana Dlugosza w Czestochowie

Vratislav Langer

Chalmers, Kemi och kemiteknik, Energi och material, Oorganisk miljökemi

K. Cihalova

Mendelova univerzita v Brne

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

D. Chudobova

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

Mendelova univerzita v Brne

R. Vesely

Masaryk University

V. Adam

Mendelova univerzita v Brne

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

R. Kizek

Mendelova univerzita v Brne

Vysoke Uceni Technicke v Brne, Stredoevropsku Technologicku Institut

Molecules

1420-3049 (ISSN)

Vol. 20 10360-10376

Ämneskategorier

Organisk kemi

DOI

10.3390/molecules200610360

PubMed

26053490