Age-contingent influence over accumbal neurotransmission and the locomotor stimulatory response to acute and repeated administration of nicotine in Wistar rats
Artikel i vetenskaplig tidskrift, 2015
Nicotine addiction is one of the leading contributors to the global burden of disease, and early onset smokers report a more severe addiction with lower chance of cessation than those with a late onset. Preclinical research supports an age-dependent component to the rewarding and reinforcing properties of nicotine, and the aim of this study was to. define behavioral adaptations and changes in accumbal neurotransmission that arise over 15 days of intermittent nicotine treatment (0.36 mg/kg/day) in rats of three different ages (5 weeks, 10 weeks, 36 weeks old). Repeated treatment increased the locomotor stimulatory response to nicotine in all age groups, but significantly faster in the two younger groups. In addition, nicotine decreased rearing activity in a way that sustained even after repeated administration in aged rats but not in the younger age groups. Electrophysiological field potential recordings revealed a decline in input/output function in the nucleus accumbens (NAc) of animals intermittently treated with nicotine starting at 5 weeks of age, but not in older animals. In drug naive rats, acute administration of nicotine modulated both accumbal dopamine output and excitatory transmission in a partially age dependent manner. Fifteen days of intermittent nicotine treatment did not alter the acute effect displayed by nicotine on dopamine levels or evoked field potentials. The data presented here show that both acute and repeated nicotine administration modulates accumbal neurotransmission and behavior in an age-contingent manner and that these age-dependent differences could reflect important neurobiological underpinnings associated with the increased vulnerability for nicotine-addiction in adolescents. (C) 2015 Elsevier Ltd. All rights reserved.
Neurosciences
SGELD U
Dopamine
CONDITIONED PLACE PREFERENCE
1989
Nucleus accumbens
ACETYLCHOLINE-RECEPTOR BLOCKADE
ELEVATED PLUS-MAZE
LONG-LASTING DISINHIBITION
1979
EXPERIMENTAL BRAIN RESEARCH
FSUD JC
NUCLEUS-ACCUMBENS
P575
SOMATODENDRITIC DOPAMINE RELEASE
CHOLINERGIC INTERNEURONS
Behavioral sensitization
Microdialysis
VENTRAL TEGMENTAL AREA
P365
Electrophysiology
CROSS-SENSITIZATION
Pharmacology & Pharmacy
FREELY MOVING RATS
V478
V34
BRAIN RESEARCH
Författare
Louise Adermark
Göteborgs universitet
Julia Morud
Göteborgs universitet
Amin Lotfi
Göteborgs universitet
Susanne Jonsson
Göteborgs universitet
Bo Söderpalm
Göteborgs universitet
Mia Ericson
Göteborgs universitet
Neuropharmacology
0028-3908 (ISSN)
Vol. 97 104-112Ämneskategorier (SSIF 2011)
Neurovetenskaper
Farmakologi och toxikologi
DOI
10.1016/j.neuropharm.2015.06.001