Age-contingent influence over accumbal neurotransmission and the locomotor stimulatory response to acute and repeated administration of nicotine in Wistar rats
Artikel i vetenskaplig tidskrift, 2015

Nicotine addiction is one of the leading contributors to the global burden of disease, and early onset smokers report a more severe addiction with lower chance of cessation than those with a late onset. Preclinical research supports an age-dependent component to the rewarding and reinforcing properties of nicotine, and the aim of this study was to. define behavioral adaptations and changes in accumbal neurotransmission that arise over 15 days of intermittent nicotine treatment (0.36 mg/kg/day) in rats of three different ages (5 weeks, 10 weeks, 36 weeks old). Repeated treatment increased the locomotor stimulatory response to nicotine in all age groups, but significantly faster in the two younger groups. In addition, nicotine decreased rearing activity in a way that sustained even after repeated administration in aged rats but not in the younger age groups. Electrophysiological field potential recordings revealed a decline in input/output function in the nucleus accumbens (NAc) of animals intermittently treated with nicotine starting at 5 weeks of age, but not in older animals. In drug naive rats, acute administration of nicotine modulated both accumbal dopamine output and excitatory transmission in a partially age dependent manner. Fifteen days of intermittent nicotine treatment did not alter the acute effect displayed by nicotine on dopamine levels or evoked field potentials. The data presented here show that both acute and repeated nicotine administration modulates accumbal neurotransmission and behavior in an age-contingent manner and that these age-dependent differences could reflect important neurobiological underpinnings associated with the increased vulnerability for nicotine-addiction in adolescents. (C) 2015 Elsevier Ltd. All rights reserved.

Neurosciences

SGELD U

Dopamine

CONDITIONED PLACE PREFERENCE

1989

Nucleus accumbens

ACETYLCHOLINE-RECEPTOR BLOCKADE

ELEVATED PLUS-MAZE

LONG-LASTING DISINHIBITION

1979

EXPERIMENTAL BRAIN RESEARCH

FSUD JC

NUCLEUS-ACCUMBENS

P575

SOMATODENDRITIC DOPAMINE RELEASE

CHOLINERGIC INTERNEURONS

Behavioral sensitization

Microdialysis

VENTRAL TEGMENTAL AREA

P365

Electrophysiology

CROSS-SENSITIZATION

Pharmacology & Pharmacy

FREELY MOVING RATS

V478

V34

BRAIN RESEARCH

Författare

Louise Adermark

Göteborgs universitet

Julia Morud

Göteborgs universitet

Amin Lotfi

Göteborgs universitet

Susanne Jonsson

Göteborgs universitet

Bo Söderpalm

Göteborgs universitet

Mia Ericson

Göteborgs universitet

Neuropharmacology

0028-3908 (ISSN)

Vol. 97 104-112

Ämneskategorier

Neurovetenskaper

Farmakologi och toxikologi

DOI

10.1016/j.neuropharm.2015.06.001