COPD Patients Have Short Lung Magnetic Resonance T1 Relaxation Time.
Artikel i vetenskaplig tidskrift, 2016

Magnetic resonance imaging (MRI) may provide attractive biomarkers for assessment of pulmonary disease in clinical trials as it is free from ionizing radiation, minimally invasive and allows regional information. The aim of this study was to characterize lung MRI T1 relaxation time as a biomarker of chronic obstructive pulmonary disease (COPD); and specifically its relationship to smoking history, computed tomography (CT), and pulmonary function test (PFT) measurements in comparison to healthy age-matched controls. Lung T1 and inter-quartile range (IQR) of T1 maps from 24 COPD subjects and 12 healthy age-matched non-smokers were retrospectively analyzed from an institutional review board approved study. The subjects underwent PFTs and two separate MR imaging sessions at 1.5 tesla to test T1 repeatability. CT scans were performed on the COPD subjects. T1 repeatability (intraclass correlation coefficient) was 0.72 for repeated scans acquired on two visits. The lung T1 was significantly shorter (p < 0.0001) and T1 IQR was significantly larger (p = 0.0002) for the COPD subjects compared to healthy controls. Lung T1 significantly (p = 0.001) correlated with lung density assessed with CT. Strong significant correlations (p < 0.0001) between lung T1 and all PFT measurements were observed. Cigarette exposure did not correlate with lung T1 in COPD subjects. In conclusion, lung MRI T1 mapping shows potential as a repeatable, radiation free, non-invasive imaging technique in the evaluation of COPD.

biomarker

longitudinal relaxation time

lung imaging

magnetic resonance imaging (MRI)

chronic obstructive pulmonary disease (COPD)

smoking

Författare

Daniel Alamidi

Göteborgs universitet

Alexandra R Morgan

Bioxydyn

University of Manchester

Penny L Hubbard Cristinacce

University of Manchester

Lars H Nordenmark

AstraZeneca AB

Paul Hockings

Chalmers, Signaler och system, Signalbehandling och medicinsk teknik, Signalbehandling

Kerstin M Lagerstrand

Göteborgs universitet

Simon S Young

AstraZeneca AB

Josephine H Naish

University of Manchester

John C Waterton

University of Manchester

Niall C Maguire

Bioxydyn

Lars E Olsson

Lunds universitet

Geoffrey J M Parker

University of Manchester

Bioxydyn

COPD: Journal of Chronic Obstructive Pulmonary Disease

1541-2555 (ISSN) 1541-2563 (eISSN)

Vol. 13 2 153-159

Ämneskategorier

Radiologi och bildbehandling

DOI

10.3109/15412555.2015.1048851

PubMed

26488310

Mer information

Senast uppdaterat

2018-09-06