Prognostic Significance of Resting Heart Rate and Use of beta-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Swedish Heart Failure Registry
Artikel i vetenskaplig tidskrift, 2015
BACKGROUND: In heart failure and reduced ejection fraction, the prognostic role of heart rate (HR) in atrial fibrillation (AF) is unknown and the effectiveness of beta-blockers has recently been questioned in AF. METHODS AND RESULTS: A total of 18 858 patients with heart failure and reduced ejection fraction registered with Swedish Heart Failure Registry were included in this study: patients with sinus rhythm (SR; n=11 466) and patients with AF (n=7392). The outcome measure was all-cause mortality. Compared with HR 100 beats per minute. However, in AF, the hazard ratio increased only for HR >100 beats per minute (1.30; P=0.001). beta-blocker use was associated with reduced mortality in SR (hazard ratio, 0.77; P=0.011) and in AF (hazard ratio, 0.71; P<0.001). For beta-blocker use in SR, the hazard ratio gradually increased with HR increment, whereas in AF, the hazard ratio significantly increased only for HR >100 beats per minute (1.29; P=0.003) compared with HR 100 beats per minute. beta-blocker use was associated with reduced mortality both in SR and in AF.
Aged
Middle Aged
Treatment Outcome
Heart Rate/drug effects/*physiology
Stroke Volume/*physiology
*Registries
Adrenergic beta-Antagonists/*therapeutic use
Heart Failure/complications/drug therapy/*physiopathology
Prognosis
Rest/*physiology
Aged
Humans
Male
Atrial Fibrillation/complications/drug therapy/*physiopathology
80 and over
Female
Författare
S. J. Li
U. Sartipy
L. H. Lund
U. Dahlstrom
Martin Adiels
Göteborgs universitet
Max Petzold
Göteborgs universitet
Michael Fu
Circulation. Heart failure
1941-3289 (ISSN) 1941-3297 (eISSN)
Vol. 8 5 871-9Ämneskategorier
Klinisk medicin
DOI
10.1161/CIRCHEARTFAILURE.115.002285
PubMed
26243796