Prognostic Significance of Resting Heart Rate and Use of beta-Blockers in Atrial Fibrillation and Sinus Rhythm in Patients With Heart Failure and Reduced Ejection Fraction: Findings From the Swedish Heart Failure Registry
Artikel i vetenskaplig tidskrift, 2015

BACKGROUND: In heart failure and reduced ejection fraction, the prognostic role of heart rate (HR) in atrial fibrillation (AF) is unknown and the effectiveness of beta-blockers has recently been questioned in AF. METHODS AND RESULTS: A total of 18 858 patients with heart failure and reduced ejection fraction registered with Swedish Heart Failure Registry were included in this study: patients with sinus rhythm (SR; n=11 466) and patients with AF (n=7392). The outcome measure was all-cause mortality. Compared with HR 100 beats per minute. However, in AF, the hazard ratio increased only for HR >100 beats per minute (1.30; P=0.001). beta-blocker use was associated with reduced mortality in SR (hazard ratio, 0.77; P=0.011) and in AF (hazard ratio, 0.71; P<0.001). For beta-blocker use in SR, the hazard ratio gradually increased with HR increment, whereas in AF, the hazard ratio significantly increased only for HR >100 beats per minute (1.29; P=0.003) compared with HR 100 beats per minute. beta-blocker use was associated with reduced mortality both in SR and in AF.

Aged

Middle Aged

Treatment Outcome

Heart Rate/drug effects/*physiology

Stroke Volume/*physiology

*Registries

Adrenergic beta-Antagonists/*therapeutic use

Heart Failure/complications/drug therapy/*physiopathology

Prognosis

Rest/*physiology

Aged

Humans

Male

Atrial Fibrillation/complications/drug therapy/*physiopathology

80 and over

Female

Författare

S. J. Li

U. Sartipy

L. H. Lund

U. Dahlstrom

Martin Adiels

Göteborgs universitet

Max Petzold

Göteborgs universitet

Michael Fu

Circulation. Heart failure

1941-3289 (ISSN) 1941-3297 (eISSN)

Vol. 8 871-9

Ämneskategorier

Klinisk medicin

DOI

10.1161/CIRCHEARTFAILURE.115.002285

PubMed

26243796