Elucidating Host-Pathogen Interactions Based on Post-Translational Modifications Using Proteomics Approaches
Övrig text i vetenskaplig tidskrift, 2015

Microbes with the capability to survive in the host tissue and efficiently subvert its innate immune responses can cause various health hazards. There is an inherent need to understand microbial infection patterns and mechanisms in order to develop efficient therapeutics. Microbial pathogens display host specificity through a complex network of molecular interactions that aid their survival and propagation. Co-infection states further lead to complications by increasing the microbial burden and risk factors. Quantitative proteomics based approaches and post-translational modification analysis can be efficiently applied to gain an insight into the molecular mechanisms involved. The measurement of the proteome and post-translationally modified proteome dynamics using mass spectrometry, results in a wide array of information, such as significant changes in protein expression, protein abundance, the modification status, the site occupancy level, interactors, functional significance of key players, potential drug targets, etc. This mini review discusses the potential of proteomics to investigate the involvement of post-translational modifications in bacterial pathogenesis and host pathogen interactions.

Microbiology

pathogenesis

mycobacterium-tuberculosis

bacteria

streptococcus-pyogenes

post-translational modifications

mass-spectrometry

virulence-determinant

salmonella-typhimurium

yersinia-protein-kinase

proteomics

top-down

co-cultures

small gtpase rab1

immune-responses

legionella-pneumophila

Författare

Vaishnavi Ravikumar

Chalmers, Biologi och bioteknik, Systembiologi

C. Jers

Danmarks Tekniske Universitet (DTU)

Ivan Mijakovic

Chalmers, Biologi och bioteknik, Systembiologi

Frontiers in Microbiology

1664-302X (ISSN)

Vol. 6 NOV 1312

Ämneskategorier

Mikrobiologi

DOI

10.3389/fmicb.2015.01312

Mer information

Senast uppdaterat

2021-07-12