Extremely low-frequency magnetic fields and risk of childhood leukemia: A risk assessment by the ARIMMORA consortium
Artikel i övriga tidskrifter, 2016

Exposure to extremely low-frequency magnetic fields (ELF-MF) was evaluated in an International Agency for Research on Cancer (IARC) Monographs as possibly carcinogenic to humans in 2001, based on increased childhood leukemia risk observed in epidemiological studies. We conducted a hazard assessment using available scientific evidence published before March 2015, with inclusion of new research findings from the Advanced Research on Interaction Mechanisms of electroMagnetic exposures with Organisms for Risk Assessment (ARIMMORA) project. The IARC Monograph evaluation scheme was applied to hazard identification. In ARIMMORA for the first time, a transgenic mouse model was used to mimic the most common childhood leukemia: new pathogenic mechanisms were indicated, but more data are needed to draw definitive conclusions. Although experiments in different animal strains showed exposure-related decreases of CD8+ T-cells, a role in carcinogenesis must be further established. No direct damage of DNA by exposure was observed. Overall in the literature, there is limited evidence of carcinogenicity in humans and inadequate evidence of carcinogenicity in experimental animals, with only weak supporting evidence from mechanistic studies. New exposure data from ARIMMORA confirmed that if the association is nevertheless causal, up to 2% of childhood leukemias in Europe, as previously estimated, may be attributable to ELF-MF. In summary, ARIMMORA concludes that the relationship between ELF-MF and childhood leukemia remains consistent with possible carcinogenicity in humans. While this scientific uncertainty is dissatisfactory for science and public health, new mechanistic insight from ARIMMORA experiments points to future research that could provide a step-change in future assessments. Bioelectromagnetics. 37:183-189, 2016.

fetal exposure

hazard identification

pooled analysis

cancer

adverse effects

children

electromagnetic fields

electromagnetic-fields

risk assessment

leukemia

acute lymphoblastic-leukemia

Författare

J Schüz

International Agency for Research on Cancer

C. Dasenbrock

Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM

P. Ravazzani

Consiglio Nazionale delle Ricerche

M Röösli

Swiss Tropical and Public Health Institute (Swiss TPH)

P. Schar

Universität Basel

P. L. Bounds

Foundation for Research on Information Technologies in Society (ITIS)

F. Erdmann

International Agency for Research on Cancer

A. Borkhardt

Heinrich Heine Universitat

C. Cobaleda

CSIC-UAM - Centro de Biología Molecular Severo Ochoa (CBM)

M. Fedrowitz

Tierarztliche Hochschule Hannover

Yngve Hamnerius

Signaler och system, Signalbehandling och medicinsk teknik, Biomedicinsk elektromagnetik

I. Sanchez-Garcia

Consejo Superior de Investigaciones Científicas

R. Seger

Weizmann Institute of Science Israel

K. Schmiegelow

Copenhagen University Hospital

G. Ziegelberger

Bundesamt fur Strahlenschutz

M. Capstick

Foundation for Research on Information Technologies in Society (ITIS)

M. Manser

Universität Basel

M. Muller

Fraunhofer Institut fur Toxikologie und Experimentelle Medizin - ITEM

C. D. Schmid

Swiss Tropical and Public Health Institute (Swiss TPH)

D. Schurmann

Universität Basel

B. Struchen

Swiss Tropical and Public Health Institute (Swiss TPH)

N. Kuster

Foundation for Research on Information Technologies in Society (ITIS)

Bioelectromagnetics

0197-8462 (ISSN) 1521-186X (eISSN)

Vol. 37 183-189

Ämneskategorier

Farmakologi och toxikologi

Styrkeområden

Livsvetenskaper och teknik

DOI

10.1002/bem.21963