Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels
Artikel i vetenskaplig tidskrift, 2016

Background: Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. Methods: HIV-1-infected ART naive adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Results: Viral blips were found in 76/735 included subjects (10.3 %) and in 90/4449 samples (2.0 %). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170 weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log(10) 4.85 copies/mL) compared with subjects without blips (median log(10) 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). Conclusions: The Swedish national HIV-cohort has a low incidence of viral blips (10 %). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure.

Viral blip

HIV-1

Transient viremia

Antiretroviral therapy

Författare

Erik Sörstedt

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

A. Blaxhult

Södersjukhuset

Magnus Gisslén

Göteborgs universitet

Leo Flamholc

Skånes universitetssjukhus (SUS)

A. Sonnerborg

Karolinska universitetssjukhuset

Aylin Yilmaz

Göteborgs universitet

BMC Infectious Diseases

1471-2334 (ISSN)

Vol. 16 1 article number 305- 305

Ämneskategorier

Infektionsmedicin

DOI

10.1186/s12879-016-1628-6

PubMed

27329293

Mer information

Senast uppdaterat

2018-05-14