Investigation of calcium phosphate formation from calcium propionate and triethyl phosphate
Artikel i vetenskaplig tidskrift, 2016

Synthetic calcium phosphates are used in for example bone cements and implant coatings to increase biocompatibility. The common method to produce tricalcium phosphate (TCP) uses high temperatures, which creates large crystals with low specific surface areas. In order to investigate new methods to produce TCP at lower temperatures, the reaction between calcium propionate and triethyl phosphate conducted at 220 degrees C was studied. The method had a near 100% conversion rate, the main synthesis products were calcium phosphate and ethyl propionate. The formed calcium phosphate polymorph could be controlled depending on the water content of the precursor mixture. Anhydrous conditions created amorphous calcium phosphate. As the concentration of water increased, beta-TCP was formed, followed by calcium deficient hydroxyapatite and monetite. The particle size increased with the water content, from 20 to 40 nm for amorphous calcium phosphate to tenths of micrometers for monetite. The specific surface areas varied between 209 m(2)/g for the amorphous product to 3.6 m(2)/g for the monetite product.

TCP

Nanocrystals

Materials Science

hydrothermal synthesis

Bone cements

regeneration

hydroxyapatite

crystal

beta-tricalcium-phosphate

Calcium phosphates

Författare

P. Kjellin

AstraZeneca AB

Anand Kumar Rajasekharan

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Teknisk ytkemi

F Currie

AstraZeneca AB

P. Handa

AstraZeneca AB

Ceramics International

0272-8842 (ISSN)

Vol. 42 12 14061-14065

Ämneskategorier

Keramteknik

DOI

10.1016/j.ceramint.2016.06.013