No support for premature central nervous system aging in HIV-1 when measured by cerebrospinal fluid phosphorylated tau (p-tau)
Artikel i vetenskaplig tidskrift, 2017

The prevalence of neurocognitive deficits are reported to be high in HIV-1 positive patients, even with suppressive antiretroviral treatment, and it has been suggested that HIV can cause accelerated aging of the brain. In this study we measured phosphorylated tau (p-tau) in cerebrospinal fluid (CSF) as a potential marker for premature central nervous system (CNS) aging. P-tau increases with normal aging but is not affected by HIV-associated neurocognitive disorders.

Författare

Jan Jessen Krut

Göteborgs universitet

R.W. Price

University of California

Henrik Zetterberg

Göteborgs universitet

Dietmar Fuchs

Medizinische Universität Innsbruck

Lars Hagberg

Göteborgs universitet

Aylin Yilmaz

Göteborgs universitet

Paola Cinque

IRCCS San Raffaele Scientific Institute

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Matematisk statistik

Göteborgs universitet

Magnus Gisslén

Göteborgs universitet

Virulence

2150-5594 (ISSN) 2150-5608 (eISSN)

Vol. 8 5 599-604

Ämneskategorier

Neurovetenskaper

DOI

10.1080/21505594.2016.1212155

PubMed

27435879

Mer information

Senast uppdaterat

2024-08-14