Biobased production of alkanes and alkenes through metabolic engineering of microorganisms
Artikel i vetenskaplig tidskrift, 2017

Advancement in metabolic engineering of microorganisms has enabled bio-based production of a range of chemicals, and such engineered microorganism can be used for sustainable production leading to reduced carbon dioxide emission there. One area that has attained much interest is microbial hydrocarbon biosynthesis, and in particular, alkanes and alkenes are important high-value chemicals as they can be utilized for a broad range of industrial purposes as well as 'drop-in' biofuels. Some microorganisms have the ability to biosynthesize alkanes and alkenes naturally, but their production level is extremely low. Therefore, there have been various attempts to recruit other microbial cell factories for production of alkanes and alkenes by applying metabolic engineering strategies. Here we review different pathways and involved enzymes for alkane and alkene production and discuss bottlenecks and possible solutions to accomplish industrial level production of these chemicals by microbial fermentation.

rate

Alkanes/alkenes

Fatty acid biosynthesis

and yield)

Metabolic engineering

TRY (titer

Cell factories

Författare

Min-Kyoung Kang

Chalmers University of Technology

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

Journal of Industrial Microbiology and Biotechnology

1367-5435 (ISSN) 1476-5535 (eISSN)

Vol. 44 613-622

Ämneskategorier

Industriell bioteknik

Styrkeområden

Energi

Livsvetenskaper och teknik

DOI

10.1007/s10295-016-1814-y

PubMed

27565672