Biomimetic Oxidative Carbene Catalysis: Enabling Aerial Oxygen as a Terminal Oxidant
Artikel i vetenskaplig tidskrift, 2017

Oxidative carbene catalysis is a quickly growing field in organic synthesis. However, these catalytic protocols traditionally rely on the stoichiometric addition of a high-molecular-weight oxidant, providing these reactions with a high E-factor. Here, we review efforts to replace high-molecular-weight oxidants with oxygen using a biomimetic system of coupled electron-transfer mediators. Two reactions are discussed: the aerobic oxidative esterification of aldehydes and the aerobic oxidative NHC-catalyzed enantioselective formation of dihydropyranones.

asymmetric synthesis

green chemistry

NHC - aerobic oxidation - oxygen


biomimetic synthesis


Anton Axelsson

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Linda Ta

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Henrik Sundén

Chalmers, Kemi och kemiteknik, Kemi och biokemi


0936-5214 (ISSN) 1437-2096 (eISSN)

Vol. 28 08 873-878 st-2016-p0816-sp



Organisk kemi



Mer information

Senast uppdaterat