Imaging atherosclerosis in rheumatoid arthritis: evidence for increased prevalence, altered phenotype and a link between systemic and localised plaque inflammation
Artikel i vetenskaplig tidskrift, 2017

In rheumatoid arthritis (RA), chronic inflammation is thought to drive increased cardiovascular risk through accelerated atherosclerosis. It may also lead to a more high-risk plaque phenotype. We sought to investigate carotid plaque phenotype in RA patients using Dynamic Contrast-Enhanced MRI (DCEMRI) and Fludeoxyglucose Positron Emission Tomography(FDG-PET). In this pilot study, RA patients and age/sex-matched controls were evaluated for cardiovascular risk factors and carotid plaque on ultrasound. Subjects with plaque >2 mm thick underwent DCE-MRI, and a subgroup of patients had FDG-PET. Comparison of MRI findings between groups and correlation between clinical, serological markers and imaging findings was undertaken. 130 patients and 62 controls were recruited. Plaque was more prevalent in the RA group (53.1% vs 37.0%, p = 0.038) and was independently associated with IL6 levels (HR[95% CI]: 2.03 [1.26, 3.26] per quartile). DCE-MRI data were available in 15 patients and 5 controls. Higher prevalence of plaque calcification was noted in RA, despite similar plaque size (73.3% vs 20%, p = 0.04). FDG-PET detected plaque inflammation in 12/13 patients scanned and degree of inflammation correlated with hs-CRP (r = 0.58, p = 0.04). This study confirms increased prevalence of atherosclerosis in RA and provides data to support the hypothesis that patients have a high-risk plaque phenotype.

Författare

[Person 1a7e6e3b-8f34-405c-be4d-01e6838cad58 not found]

Christie Hospital NHS Foundation Trust

University of Manchester

[Person 998848bd-4e33-47a6-a2ea-e3695b95ec5b not found]

University of Manchester

[Person bcc064bd-1d0e-465e-827a-28e2096e5b92 not found]

Christie Hospital NHS Foundation Trust

[Person 71d25302-7cd6-4b22-b65b-06aa54212cde not found]

Christie Hospital NHS Foundation Trust

[Person 2153607a-1cb8-44ed-8f94-8268615d8418 not found]

University of Washington

[Person b1d55f99-8bbd-4f54-924a-df5805eeffce not found]

University of Washington

[Person a1567e3b-716c-4c7c-ac1d-0a085340ed0e not found]

Christie Hospital NHS Foundation Trust

[Person 17b353dc-42ab-4f06-8c5a-dccec82adb2f not found]

University of Washington

[Person 5b13d77a-849f-4b08-9ca2-2ca4a239872d not found]

University of Washington

[Person 2523e9dc-855d-4283-a06f-e4eec727b16b not found]

Chalmers, Signaler och system, Signalbehandling och medicinsk teknik, Signalbehandling

[Person dde114dc-14b1-47b3-851c-dc1e254eb7c9 not found]

Manchester Metropolitan University

[Person 25052398-df65-47eb-b1dd-900bf41cdf05 not found]

University of Manchester

[Person 28f8acce-39c3-488c-898a-80efe984c3ed not found]

University of Manchester

Christie Hospital NHS Foundation Trust

Scientific Reports

2045-2322 (ISSN)

Vol. 7 1 827

Ämneskategorier

Bioprocessteknik

Styrkeområden

Livsvetenskaper och teknik (2010-2018)

DOI

10.1038/s41598-017-00989-w

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Senast uppdaterat

2018-03-19