Systems Biology of Metabolism
Reviewartikel, 2017
Metabolism is highly complex and involves thousands of different connected reactions; it is therefore necessary to use mathematical models for holistic studies. The use of mathematical models in biology is referred to as systems biology. In this review, the principles of systems biology are described, and two different types of mathematical models used for studying metabolism are discussed: kinetic models and genome-scale metabolic models. The use of different omics technologies, including transcriptomics, proteomics, metabolomics, and fluxomics, for studying metabolism is presented. Finally, the application of systems biology for analyzing global regulatory structures, engineering the metabolism of cell factories, and analyzing human diseases is discussed.
genome-scale metabolic models
Genome-Scale Models
In-Vivo Analysis
Reductive Glutamine-Metabolism
Gene-Expression
systems
Gut Microbiota
Saccharomyces-Cerevisiae
metabolomics
Global
Escherichia-Coli
Reconstruction proteomics
metabolic engineering
Mitochondrial Pyruvate Carrier
Flux Analysis
Författare
Jens B Nielsen
Chalmers, Biologi och bioteknik, Systembiologi
Annual Review of Biochemistry
0066-4154 (ISSN) 1545-4509 (eISSN)
Vol. 86 245-275Ämneskategorier
Bioinformatik och systembiologi
DOI
10.1146/annurev-biochem-061516-044757