Visceral Fat and Novel Biomarkers of Cardiovascular Disease in Patients With Addison's Disease: A Case-Control Study
Artikel i vetenskaplig tidskrift, 2017

Context: Patients with Addison's disease (AD) have increased cardiovascular mortality. Objective: To study visceral fat and conventional and exploratory cardiovascular risk factors in patients with AD. Subjects: Patients (n = 76; n = 51 women) with AD and 76 healthy control subjects were matched for sex, age, body mass index (BMI), and smoking habits. Main outcome measures: The primary outcome variable was visceral abdominal adipose tissue (VAT) measured using computed tomography. Secondary outcome variables were prevalence of metabolic syndrome (MetS) and 92 biomarkers of cardiovascular disease. Results: The mean 6 standard deviation age of all subjects was 53 6 14 years; mean BMI, 25 6 4 kg/ m2; and mean duration of AD, 17 6 12 years. The median (range) daily hydrocortisone dose was 30 mg (10 to 50 mg). Median (interquartile range) 24-hour urinary free cortisol excretion was increased in patients vs controls [359 nmol (193 to 601 nmol) vs 175 nmol (140 to 244 nmol); P, 0.001]. VAT did not differ between groups. After correction for multiple testing, 17 of the 92 studied biomarkers differed significantly between patients and control subjects. Inflammatory, proinflammatory, and proatherogenic risk biomarkers were increased in patients [fold change (FC),.1] and vasodilatory protective marker was decreased (FC, < 1). Twenty-six patients (34%) vs 12 control subjects (16%) fulfilled the criteria for MetS (P = 0.01). Conclusion: Despite higher cortisol exposure, VAT was not increased in patients with AD. The prevalence of MetS was increased and several biomarkers of cardiovascular disease were adversely affected in patients with AD.

Författare

Ragnhildur Bergthorsdottir

Sahlgrenska universitetssjukhuset

Sahlgrenska akademin

Oskar Ragnarsson

Sahlgrenska akademin

Sahlgrenska universitetssjukhuset

Stanko Skrtic

AstraZeneca AB

Sahlgrenska akademin

Sahlgrenska universitetssjukhuset

Camilla A M Glad

Sahlgrenska universitetssjukhuset

Sahlgrenska akademin

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

I. L. Ross

University of Cape Town

Maria Leonsson-Zachrisson

AstraZeneca AB

Gudmundur Johannsson

Sahlgrenska universitetssjukhuset

Sahlgrenska akademin

Journal of Clinical Endocrinology and Metabolism

0021-972X (ISSN)

Vol. 102 11 4264-4272

Ämneskategorier

Kardiologi

DOI

10.1210/jc.2017-01324

PubMed

28945861

Mer information

Senast uppdaterat

2018-04-17