Serum C-reactive protein concentration and genotype in relation to ischemic stroke subtype
Artikel i vetenskaplig tidskrift, 2006

BACKGROUND AND PURPOSE: C-reactive protein (CRP) has evolved as an inflammatory risk marker of cardiovascular disease. Several single-nucleotide polymorphisms at the CRP locus have been found to be associated with CRP levels. The aim of the present study was to investigate CRP levels and genetic variants in etiological subtypes of ischemic stroke. METHODS: The Sahlgrenska Academy Study on Ischemic Stroke (SAHLSIS) comprises 600 consecutive ischemic stroke cases (18 to 69 years) and 600 matched controls from western Sweden. Stroke subtypes were defined by the TOAST classification. Serum CRP levels were determined by a high-sensitivity immunometric assay. RESULTS: CRP levels were significantly higher for all ischemic stroke subtypes compared with controls, both in the acute phase and at the 3-month follow-up. After adjustment for traditional risk factors, CRP at follow-up was related to higher odds ratios (ORs) of overall ischemic stroke (OR, 1.25; 95% CI, 1.09 to 1.43) and large-vessel disease (OR, 1.48; 95% CI, 1.09 to 2.00). The CRP -286C>T>A, 1059G>C, and 1444C>T single-nucleotide polymorphisms showed significant associations with CRP levels. However, neither CRP genotypes nor haplotypes showed an association to overall ischemic stroke. CONCLUSIONS: This is the first large study on CRP in different TOAST subtypes in a young ischemic stroke population. CRP levels differed between etiological subtypes of ischemic stroke both in the acute phase and at the 3-month follow-up. CRP at follow-up was associated with overall ischemic stroke and the large-vessel disease subtype. Genetic variants at the CRP locus were associated with CRP levels, but no association was detected for overall ischemic stroke.

Brain Ischemia/*blood/complications/*genetics

Osmolar Concentration

C-Reactive Protein/*genetics/*metabolism

Case-Control Studies

Adult

*Variation (Genetics)

Cerebral Infarction/blood/etiology/physiopathology

Cerebrovascular Accident/*blood/classification/*genetics

Middle Aged

Haplotypes

Genotype

Humans

Aged

Författare

Claes Ladenvall

Göteborgs universitet

Katarina Jood

Göteborgs universitet

Christian Blomstrand

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Christina Jern

Göteborgs universitet

Per Ladenvall

Göteborgs universitet

Stroke

0039-2499 (ISSN) 1524-4628 (eISSN)

Vol. 37 8 2018-23

Ämneskategorier

Dermatologi och venereologi

PubMed

16809555