Bone reaction to nano hydroxyapatite modified titanium implants placed in a gap-healing model
Artikel i vetenskaplig tidskrift, 2008

Nanohydroxyapatite materials show similar chemistry to the bone apatite and depending on the underlying topography and the method of preparation, the nanohydroxyapatite may simulate the specific arrangement of the crystals in bone. Hydroxyapatite (HA) and other CaP materials have been indicated in cases in which the optimal surgical fit is not achievable during surgery, and the HA surface properties may enhance bone filling of the defect area. In this study, very smooth electropolished titanium implants were used as substrata for nano-HA surface modification and as control. One of each implant (control and nano HA) was placed in the rabbit tibia in a surgical site 0.7 mm wider than the implant diameter, resulting in a gap of 0.35 mm on each implant side. Implant stability was ensured by a fixating plate fastened with two side screws. Topographical evaluation performed with an optical interferometer revealed the absence of microstructures on both implants and higher resolution evaluation with AFM showed similar nanoroughness parameters. Surface pores detected on the AFM measurements had similar diameter, depth, and surface porosity (%). Histological evaluation demonstrated similar bone formation for the nano HA and electropolished implants after 4 weeks of healing. These results do not support that nano-HA chemistry and nanotopography will enhance bone formation when placed in a gap-healing model. The very smooth surface may have prevented optimal activity of the material and future studies may evaluate the synergic effects of the surface chemistry, micro, and nanotopography, establishing the optimal parameters for each of them.

nanostructures

osseointegration

hydroxyapatite

bone defect

in vivo test

nanotopography

Författare

Luiz Meirelles

Göteborgs universitet

Tomas Albrektsson

Göteborgs universitet

Per Kjellin

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Anna Arvidsson

Göteborgs universitet

Victoria Franke Stenport

Göteborgs universitet

Martin Andersson

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Fredrik Currie

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

Ann Wennerberg

Göteborgs universitet

Journal of Biomedical Materials Research - Part A

1549-3296 (ISSN)

Vol. 87 3 624-631

Ämneskategorier

Odontologi

DOI

10.1002/jbm.a.31736

Mer information

Skapat

2017-10-07