Identification of genes predominantly expressed in human macrophages
Artikel i vetenskaplig tidskrift, 2004

Identification of cell and tissue specific genes may provide novel insights to signaling systems and functions. Macrophages play a key role in many diseases including atherosclerosis. Using DNA microarrays we compared the expression of approximately 10,000 genes in 56 human tissues and identified 23 genes with predominant expression in macrophages. The identified genes include both genes known to be macrophage specific and genes previously not well described in this cell type. Tissue distribution of two genes, liver X receptor (LXR) alpha and interleukin-1 receptor antagonist (IL1RN), was verified by real-time RT-PCR. We conclude that comparison of expression profiles from a large number of tissues can be used to identify genes that are predominantly expressed in certain tissues. Identification of novel macrophage specific genes may increase our understanding of the role of this cell in different diseases.

Oligonucleotide Array Sequence Analysis

Humans

Tissue Distribution

Interleukin 1 Receptor Antagonist Protein

Cytoplasmic and Nuclear/*genetics

Receptors

Macrophages/chemistry/*physiology

Sialoglycoproteins/*genetics

DNA-Binding Proteins

Författare

Per Anders Svensson

Göteborgs universitet

Daniel Hägg

Göteborgs universitet

Margareta Jernås

Göteborgs universitet

Mikael Englund

Göteborgs universitet

Lillemor Mattsson Hultén

Göteborgs universitet

Bertil Ohlsson

Göteborgs universitet

Johannes Hulthe

Göteborgs universitet

Olov Wiklund

Göteborgs universitet

Björn Carlsson

Göteborgs universitet

Björn Fagerberg

Göteborgs universitet

Lena M S Carlsson

Göteborgs universitet

Atherosclerosis

Vol. 177 2 287-90

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP