Nanomaterial interactions with biomembranes: Bridging the gap between soft matter models and biological context
Artikel i vetenskaplig tidskrift, 2018

Synthetic polymers, nanoparticles, and carbon-based materials have great potential in applications including drug delivery, gene transfection, in vitro and in vivo imaging, and the alteration of biological function. Nature and humans use different design strategies to create nanomaterials: biological objects have emerged from billions of years of evolution and from adaptation to their environment resulting in high levels of structural complexity; in contrast, synthetic nanomaterials result from minimalistic but controlled design options limited by the authors' current understanding of the biological world. This conceptual mismatch makes it challenging to create synthetic nanomaterials that possess desired functions in biological media. In many biologically relevant applications, nanomaterials must enter the cell interior to perform their functions. An essential transport barrier is the cell-protecting plasma membrane and hence the understanding of its interaction with nanomaterials is a fundamental task in biotechnology. The authors present open questions in the field of nanomaterial interactions with biological membranes, including: how physical mechanisms and molecular forces acting at the nanoscale restrict or inspire design options; which levels of complexity to include next in computational and experimental models to describe how nanomaterials cross barriers via passive or active processes; and how the biological media and protein corona interfere with nanomaterial functionality. In this Perspective, the authors address these questions with the aim of offering guidelines for the development of next-generation nanomaterials that function in biological media.

Författare

Marco Werner

Universitat Rovira i Virgili

Thorsten Auth

Forschungszentrum Jülich

Paul A. Beales

University of Leeds

Jean Baptiste Fleury

Universität des Saarlandes

Fredrik Höök

Chalmers, Fysik, Biologisk fysik

Holger Kress

Universität Bayreuth

Reid C. Van Lehn

University of Wisconsin Madison

Marcus Müller

Georg-August-Universität Göttingen

Eugene P. Petrov

Max Planck-institutet

Lev Sarkisov

University of Edinburgh

Ludwig-Maximilians-Universität München

Jens Uwe Sommer

Leibniz-Institut fur Polymerforschung

Vladimir A. Baulin

Universitat Rovira i Virgili

Biointerphases

1559-4106 (ISSN) 1934-8630 (eISSN)

Vol. 13 2 028501

Ämneskategorier

Interaktionsteknik

Biofysik

Bioinformatik (beräkningsbiologi)

DOI

10.1116/1.5022145

PubMed

29614862

Mer information

Senast uppdaterat

2018-05-31