Diabetic dyslipidaemia
Artikel i vetenskaplig tidskrift, 2006

PURPOSE OF REVIEW: Diabetic dyslipidaemia is a cluster of plasma lipid and lipoprotein abnormalities that are metabolically interrelated. The increase of large type 1 very low density lipoprotein particles in type 2 diabetes initiates a sequence of events that generates atherogenic remnants, small dense low-density lipoprotein and small dense high-density lipoprotein particles. Thus, it is of great importance to elucidate the mechanisms behind the overproduction of large very low density lipoprotein particles in diabetic dyslipidaemia. This review discusses the pathophysiology of very low density lipoprotein metabolism in type 2 diabetes and recent concepts of lipid management of diabetic dyslipidaemia. RECENT FINDINGS: Results indicate that triglyceride and apolipoprotein B production in types 1 and 2 very low density lipoprotein are significantly correlated, suggesting a coupling of the two processes governing the metabolism of these lipoprotein subpopulations. Insulin resistance, hyperglycaemia, and liver fat were associated with excess hepatic production of type 1 but not type 2 very low density lipoprotein particles. These data provide support for the independent regulation of types 1 and 2 very low density lipoprotein apolipoprotein B production. SUMMARY: Recent data suggest that the assembly of very low density lipoprotein is fundamentally altered in type 2 diabetes, explaining the overproduction of large type 1 very low density lipoprotein as well as the inability of insulin to suppress production of type 1 very low density lipoprotein in type 2 diabetes. Future discoveries hopefully will delineate the regulatory steps to allow more targeted treatment of diabetic dyslipidaemia.

Apolipoproteins B/metabolism

Type

Liver/metabolism

Dyslipidemias/*complications/*metabolism/pathology/physiopathology

Diabetes Mellitus

Humans

Animals

2/*complications/*metabolism/pathology/physiopathology

Författare

Martin Adiels

Göteborgs universitet

Sven-Olof Olofsson

Göteborgs universitet

M. R. Taskinen

Jan Borén

Göteborgs universitet

Current Opinion in Lipidology

0957-9672 (ISSN) 1473-6535 (eISSN)

Vol. 17 238-46

Ämneskategorier

MEDICIN OCH HÄLSOVETENSKAP

PubMed

16680028