The potential role of statins in preeclampsia and dyslipidemia during gestation: a narrative review
Reviewartikel, 2018

Introduction: Statins have several pleiotropic effects that have the potential to be beneficial during pregnancy. This study evaluates the available evidence for the teratogenicity of statins, and their utility in treating preeclampsia and dyslipidemia in pregnancy, as good alternatives in these domains are currently lacking. Areas covered: The possible teratogenicity of statins is a primary focus of this paper. We also evaluated for some possible non-teratogenic effects, such as changes in birth weight and rates of spontaneous abortion, among mothers exposed to statins during pregnancy. Regarding potential uses, this study mainly discusses statin utility in preventing and treating preeclampsia and treating dyslipidemia in pregnancy. Within the latter, we explore the relationship between dyslipidemia and preeclampsia, the potential consequences of delaying statin therapy where indicated, and the impact of supra-physiological levels of cholesterol in utero on offspring. The literature search was conducted using Embase, Web of Science, PubMed, and Scopus. Expert opinion: Based on current evidence, statins are likely not teratogenic. Limited, but promising evidence exists for their efficacy in treating and preventing preeclampsia. In utero exposure to high cholesterol may negatively impact offspring, and should be thoroughly investigated.

teratogenesis

Statins

dyslipidemia

pregnancy

preeclampsia

Författare

Serban M. Maierean

Universitatea de Medicina si Farmacie Victor Babes din Timisoara

Dimitri P. Mikhailidis

UCL Medical School

Peter P. Toth

Johns Hopkins University

CGH Medical Center

Mariusz Grzesiak

Instytut Centrum Zdrowia Matki Polki

Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Marek Maciejewski

Medical University of Lodz

Maciej Banach

Uniwersytet Zielonogorski

Instytut Centrum Zdrowia Matki Polki

Medical University of Lodz

Expert Opinion on Investigational Drugs

1354-3784 (ISSN)

Vol. 27 5 427-435

Ämneskategorier

Annan naturresursteknik

Miljömedicin och yrkesmedicin

Reproduktionsmedicin och gynekologi

DOI

10.1080/13543784.2018.1465927

Mer information

Senast uppdaterat

2018-09-18