Dietary inflammatory index and cardiometabolic risk in US adults
Artikel i vetenskaplig tidskrift, 2018

Background and aims: We investigated the association between Dietary Inflammatory Index (DII®) scores and cardio-metabolic risk factors singly and in combination as metabolic syndrome (MetS). Methods: We used data from participants selected from the US National Health and Nutrition Examination Survey (NHANES). Analyses were restricted to participants with data available on dietary intake, biochemical data, and anthropometric measurements from 2005 to 2012. Statistical analyses used the SPSS®Complex Samples v22.0 (IBM Corp, Armonk, NY) and accounted for the survey design and sample weights. Energy-adjusted-DII (E-DII®) expressed per 1000 kcal was calculated from 24-h dietary recalls. Of the 17,689 participants with evaluable data, 8607 (48.3%) were men. The mean age was 45.8 years in the overall sample, with men being slightly younger than women (44.9 vs. 46.5 years, p = 0.05). Results: In multivariable-adjusted regression models, the odds of MetS, its components, as well as obesity, and elevated high-sensitivity C-reactive protein (hsCRP) increased across increasing quartiles of E-DII (p < 0.001). In age, sex, race, income-to-poverty ratio-adjusted models, these and other cardiovascular disease risk factors (triglycerides/high density lipoprotein cholesterol (HDL-C) ratio, apolipoprotein (B) and HbA1C) increased across quartiles of the E-DII (all p < 0.001), while HDL-C levels decreased (p < 0.001). Conclusions: This study suggests associations between MetS, its components, subclinical inflammation, and the DII. These results reinforce the view that diet plays an important role in the occurrence of cardiovascular diseases.


Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Nitin Shivappa

Connecting Health Innovations LLC

University of South Carolina

Michael D. Wirth

University of South Carolina

Connecting Health Innovations LLC

James R. Hebert

Connecting Health Innovations LLC

University of South Carolina

Dimitri P. Mikhailidis

University College London (UCL)

Andre Pascal Kengne

University of Cape Town

Maciej Banach

Medical University of Lodz

Uniwersytet Zielonogorski

Healthy Aging Research Centre (HARC)


0021-9150 (ISSN) 18791484 (eISSN)

Vol. 276 23-27



Annan klinisk medicin




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