Metabolic engineering of Saccharomyces cerevisiae for production of fatty acid–derived hydrocarbons
Reviewartikel, 2018

Fatty acid–derived hydrocarbons attract increasing attention as biofuels due to their immiscibility with water, high-energy content, low freezing point, and high compatibility with existing refineries and end-user infrastructures. Yeast Saccharomyces cerevisiae has advantages for production of fatty acid–derived hydrocarbons as its native routes toward fatty acid synthesis involve only a few reactions that allow more efficient conversion of carbon substrates. Here we describe major biosynthetic pathways of fatty acid–derived hydrocarbons in yeast, and summarize key metabolic engineering strategies, including enhancing precursor supply, eliminating competing pathways, and expressing heterologous pathways. With recent advances in yeast production of fatty acid–derived hydrocarbons, our review identifies key research challenges and opportunities for future optimization, and concludes with perspectives and outlooks for further research directions.



fatty acid



fatty alcohol


Yiming Zhang

Beijing University of Chemical Technology

Jens B Nielsen

Danmarks Tekniske Universitet (DTU)

Beijing University of Chemical Technology

Chalmers, Biologi och bioteknik, Systembiologi

Zihe Liu

Beijing University of Chemical Technology

Biotechnology and Bioengineering

0006-3592 (ISSN) 1097-0290 (eISSN)

Vol. 115 9 2139-2147


Övrig annan teknik

Kemiska processer

Biokatalys och enzymteknik



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