N-Acylation of Oxazolidinones via Aerobic Oxidative NHC Catalysis
Artikel i vetenskaplig tidskrift, 2018

The first N-acylation of synthetically useful oxazolidinones with aldehydes using aerobic oxidative NHC catalysis is reported. The reaction offers a broad scope of functionalized oxazolidinones in good to excellent yields. Careful choice of electron transfer mediators proved pivotal to achieve efficient aerobic N-acylation, which has previously proven difficult using NHC catalysis. The methodology allows a mild entry to acylated oxazolidinones, avoiding the use of hazardous and reactive prefunctionalized substrates.

Green chemistry

Aerobic Oxidations

Catalysis

N-heterocyclic carbene

Författare

Journal of Organic Chemistry

0022-3263 (ISSN) 1520-6904 (eISSN)

Vol. 83 19 12261-12268

Ämneskategorier

Kemi

Organisk kemi

DOI

10.26434/chemrxiv.6265148.v1

Mer information

Senast uppdaterat

2022-01-17