N-Acylation of Oxazolidinones via Aerobic Oxidative NHC Catalysis
Artikel i vetenskaplig tidskrift, 2018

The first N-acylation of synthetically useful oxazolidinones with aldehydes using aerobic oxidative NHC catalysis is reported. The reaction offers a broad scope of functionalized oxazolidinones in good to excellent yields. Careful choice of electron transfer mediators proved pivotal to achieve efficient aerobic N-acylation, which has previously proven difficult using NHC catalysis. The methodology allows a mild entry to acylated oxazolidinones, avoiding the use of hazardous and reactive prefunctionalized substrates.

Catalysis

Aerobic Oxidations

N-heterocyclic carbene

Green chemistry

Författare

Linda Ta

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Anton Axelsson

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Organisk kemi

Henrik Sundén

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Journal of Organic Chemistry

0022-3263 (ISSN) 1520-6904 (eISSN)

Vol. 83 19 12261-12268

Ämneskategorier

Kemi

Organisk kemi

DOI

10.1021/acs.joc.8b01723

Mer information

Skapat

2018-10-09