Inverse association between serum antioxidant levels and inflammatory markers is moderated by adiposity: a report based on a large representative population sample of American adults
Artikel i vetenskaplig tidskrift, 2018

We examined the association between plasma antioxidant levels and markers of inflammation, including C-reactive protein (CRP) and fibrinogen (FG) in US adults. National Health and Nutrition Examination Survey participants examined between 2001 and 2002 were included, if data on CRP or FG levels. Serum vitamins A and E, two retinyl esters, and six carotenoids were measured using HPLC with photodiode array detection. Multivariable-adjusted linear regression analyses accounted for the survey design and sample weights. A total of 784 eligible participants were included; 47.5 % (n 372) were men. In multivariable linear regression models, serum alpha-carotene, trans-beta-carotene, cis-beta-carotene, beta-cryptoxanthin, combined lutein/zeaxanthin, trans-lycopene, retinyl palmitate, alpha-tocopherol, retinol and 25-hydroxy vitamin D were negatively associated with serum CRP (P3 mg/l, decreased with increasing levels of antioxidants (alpha-carotene, trans-beta-carotene, cis-beta-carotene, vitamins A and E). Furthermore, we found a moderate impact of adiposity on the link between antioxidants and CRP. Our results suggest that the lower the antioxidants levels, the higher the inflammatory burden, based on CRP and FG levels. Adiposity moderately affects this association. Furthermore, an inverse relationship between CVD risk and antioxidant levels was observed. This finding suggests that reduced levels of vitamins with antioxidant properties may predispose to increased CVD risk.





Cardiovascular risk

C-reactive protein


Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Andre Pascal Kengne

University of Cape Town

Niki Katsiki

Aristotelio Panepistimio Thessalonikis

Dimitri P. Mikhailidis

University College London (UCL)

Maciej Banach

Instytut Centrum Zdrowia Matki Polki

Uniwersytet Zielonogorski

Medical University of Lodz

British Journal of Nutrition

0007-1145 (ISSN) 1475-2662 (eISSN)

Vol. 120 11 1272-1278


Endokrinologi och diabetes

Miljömedicin och yrkesmedicin






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