Selective Iron-Mediated C- and O-Addition of Phenolic Nucleophiles to a Cyclohexadiene Scaffold Using Renewable Precursors
Artikel i vetenskaplig tidskrift, 2019

Renewable phenols have been investigated as nucleophiles for the addition to a cationic cyclohexadienyl iron carbonyl scaffold. Benign conditions compatible with solvents such as ethanol and water were developed, and for the first time, selective C- or O-addition could be achieved. In addition, a novel atom-economic approach to forming the C-addition products directly from the neutral precursor complex in a single step using a catalytic acid is described. The formed C-addition product could then be selectively demetalated to form one of two different product classes, a functionalized arene or a cyclohexadiene.

Iron

Metal carbonyl

Renewable resources

Phenols

Green chemistry

Cyclohexadiene

Water

Författare

Petter Dunås

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Andrew Paterson

Chalmers, Kemi och kemiteknik, Kemi och biokemi

G. Kociok-Köhn

University of Bath

Simon E. Lewis

University of Bath

Nina Kann

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

ACS Sustainable Chemistry & Engineering

2168-0485 (eISSN)

Vol. 7 7 7155-7162

Ämneskategorier

Kemiska processer

Biokatalys och enzymteknik

Organisk kemi

DOI

10.1021/acssuschemeng.9b00127

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Senast uppdaterat

2020-07-16