Sesame oil and vitamin E co-administration may improve cardiometabolic risk factors in patients with metabolic syndrome: a randomized clinical trial
Artikel i vetenskaplig tidskrift, 2019

Objectives: Metabolic syndrome (MetS) represents a clustering of metabolic abnormalities that are associated with an increased risk of type 2 diabetes and cardiovascular disease. We aimed to evaluate the effects of sesame oil enriched with vitamin E (vit E), sesame oil alone and sunflower oil on lipid profile, fasting blood glucose (FBG), malondialdehyde (MDA), high-sensitivity C-reactive protein (Hs-CRP), homeostatic model assessment (HOMA-IR), and blood pressure (BP) in patients with MetS. Subjects: Overall, 75 individuals with MetS (aged 30–70 years) participated in this randomized, single-blind controlled trial. Patients were randomly allocated to: (1) Group A (n = 25): sesame oil (30 ml/day) enriched with vit E (400 mg/day), (2) Group B (n = 25): sesame oil (30 ml/day), (3) Group C (n = 25): sunflower oil (30 ml/day). Anthropometric data, dietary intake, blood pressure, and biochemical markers, including fasting serum lipids, FBG, serum insulin, MDA, and hs-CRP were measured at baseline and at week 8. Results: In individuals in the sesame oil enriched with vit E group (Group A), there were significant reductions in serum total cholesterol (TC), triglycerides (TG), FBG, HOMA-IR, MDA, hs-CRP, high-density lipoprotein (HDL-C) systolic and diastolic BP (for all the comparison p < 0.02). Similarly, in Group B (taking sesame oil alone), TC, TG, FBG, HOMA-IR, MDA, systolic and diastolic BP were significantly improved (for all the comparison p < 0.025), while there were no significant changes in serum HDL (baseline = 35.9 ± 7.2 mg/dL vs. 36.4 ± 6.2 mg/dL, p = 0.432) and hs-CRP (baseline = 4.38 ± 1.34 mg/dL vs. week 8 = 3.96 ± 1.7 mg/dL, p = 0.057) in second group. No significant changes in any of the studied clinical and anthropometric data were found in Group C (on sunflower oil). Conclusion: Sesame oil (±vit E) was shown to beneficially affect several cardiometabolic indices (including lipids, FBG, BP, HOMA-IR, and MDA) in patients with MetS.




biochemical marker

sesame oil

high density lipoprotein cholesterol


C reactive protein

alpha tocopherol


Ali Farajbakhsh

Shiraz University of Medical Sciences

Seyed Mohammad Mazloomi

Shiraz University of Medical Sciences

Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Peyman Rezaie

University of Adelaide

Marzieh Akbarzadeh

Shiraz University of Medical Sciences

Saeedeh Poor Ahmad

Shiraz University of Medical Sciences

G. A. Ferns

Brighton and Sussex Medical School

Richard Ofori-Asenso

Monash University

Siavash Babajafari

Shiraz University of Medical Sciences

European Journal of Clinical Nutrition

0954-3007 (ISSN)

Vol. 73 10 1403-1411


Endokrinologi och diabetes

Annan klinisk medicin




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