A cellular automaton for modeling non-trivial biomembrane ruptures
Artikel i vetenskaplig tidskrift, 2019

A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models and bond-based fracture methods. The model is demonstrated by comparing simulations with experimental results of a double bilayer lipid membrane expanding on a solid substrate. Results indicate that the CA can capture non-trivial rupture morphologies such as floral patterns and the saltatory dynamics of fractal avalanches observed in experiments. Moreover, the CA provides insight into the poorly understood role of inter-layer adhesion, supporting the hypothesis that the density of adhesion sites governs rupture morphology.


Abhay Gupta

Santa Clara University

Irep Gözen

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Universitetet i Oslo

Michael Taylor

Santa Clara University

Soft Matter

1744-683X (ISSN) 1744-6848 (eISSN)

Vol. 15 20 4178-4186

Bristande biomembran: ett fokus på grundläggande forskning, materialvetenskap, nanoteknik och hälsa

Vetenskapsrådet (VR), 2016-01-01 -- 2019-12-31.


Annan fysik


Bioinformatik (beräkningsbiologi)



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