A cellular automaton for modeling non-trivial biomembrane ruptures
Artikel i vetenskaplig tidskrift, 2019

A novel cellular automaton (CA) for simulating biological membrane rupture is proposed. Constructed via simple rules governing deformation, tension, and fracture, the CA incorporates ideas from standard percolation models and bond-based fracture methods. The model is demonstrated by comparing simulations with experimental results of a double bilayer lipid membrane expanding on a solid substrate. Results indicate that the CA can capture non-trivial rupture morphologies such as floral patterns and the saltatory dynamics of fractal avalanches observed in experiments. Moreover, the CA provides insight into the poorly understood role of inter-layer adhesion, supporting the hypothesis that the density of adhesion sites governs rupture morphology.

Författare

Abhay Gupta

Santa Clara University

Irep Gözen

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Universitetet i Oslo

Michael Taylor

Santa Clara University

Soft Matter

1744-683X (ISSN) 1744-6848 (eISSN)

Vol. 15 20 4178-4186

Bristande biomembran: ett fokus på grundläggande forskning, materialvetenskap, nanoteknik och hälsa

Vetenskapsrådet (VR), 2016-01-01 -- 2019-12-31.

Ämneskategorier

Annan fysik

Biofysik

Bioinformatik (beräkningsbiologi)

DOI

10.1039/c8sm02032a

Mer information

Senast uppdaterat

2019-06-11