Neural gain control measured through cortical gamma oscillations is associated with sensory sensitivity
Artikel i vetenskaplig tidskrift, 2019

Gamma oscillations facilitate information processing by shaping the excitatory input/output of neuronal populations. Recent studies in humans and nonhuman primates have shown that strong excitatory drive to the visual cortex leads to suppression of induced gamma oscillations, which may reflect inhibitory-based gain control of network excitation. The efficiency of the gain control measured through gamma oscillations may in turn affect sensory sensitivity in everyday life. To test this prediction, we assessed the link between self-reported sensitivity and changes in magneto-encephalographic gamma oscillations as a function of motion velocity of high-contrast visual gratings. The induced gamma oscillations increased in frequency and decreased in power with increasing stimulation intensity. As expected, weaker suppression of the gamma response correlated with sensory hypersensitivity. Robustness of this result was confirmed by its replication in the two samples: neurotypical subjects and people with autism, who had generally elevated sensory sensitivity. We conclude that intensity-related suppression of gamma response is a promising biomarker of homeostatic control of the excitation-inhibition balance in the visual cortex.

response gain control

gamma oscillations

autism spectrum disorders

sensory sensitivity

visual motion

magneto-encephalography

Författare

Elena V. Orekhova

Göteborgs universitet

Moscow State University of Psychology and Education

Tatiana A. Stroganova

Moscow State University of Psychology and Education

Justin Schneiderman

Chalmers, Mikroteknologi och nanovetenskap (MC2), Kvantkomponentfysik

MedTech West

Sebastian Lundstrom

Göteborgs universitet

Bushra Riaz

Göteborgs universitet

Darko Sarovic

Göteborgs universitet

Olga V. Sysoeva

Moscow State University of Psychology and Education

Georg Brant

MedTech West

Christopher Gillberg

Göteborgs universitet

Nouchine Hadjikhani

Göteborgs universitet

Harvard Medical School

Human Brain Mapping

1065-9471 (ISSN) 1097-0193 (eISSN)

Vol. 40 5 1583-1593

Ämneskategorier

Psykologi (exklusive tillämpad psykologi)

Neurovetenskaper

Bioinformatik (beräkningsbiologi)

DOI

10.1002/hbm.24469

PubMed

30549144

Mer information

Senast uppdaterat

2019-07-12