An update on polymer-lipid hybrid systems for improving oral drug delivery
Reviewartikel, 2019

Introduction: A promising approach that has recently emerged to overcome the complex biobarriers and interrelated challenges associated with oral drug absorption is to combine the benefits of polymeric and lipid-based nanocarriers within one hybrid system. This multifaceted formulation strategy has given rise to a plethora of polymer-lipid hybrid (PLH) systems with varying nanostructures and biological activities, all of which have demonstrated the ability to improve the biopharmaceutical performance of a wide range of challenging therapeutics.
Areas covered: The multitude of polymers that can be combined with lipids to exert a synergistic effect for oral drug delivery have been identified, reviewed and critically evaluated. Specific focus is attributed to preclinical studies performed within the past 5 years that have elucidated the role and mechanism of the polymer phase in altering the oral absorption of encapsulated therapeutics.
Expert opinion: The potential of PLH systems has been clearly identified; however, improved understanding of the structure-activity relationship between PLH systems and oral absorption is fundamental for translating this promising delivery approach into a clinically relevant formulation. Advancing research within this field to identify optimal polymer, lipid combinations and engineering conditions for specific therapeutics are therefore encouraged.


oral drug delivery

poorly soluble drugs

polymer-lipid hybrid


lipid-based formulations


proteins and peptides

drug delivery

polymeric nanoparticles


Sajedehsadat Maghrebi

University of South Australia

Clive A. Prestidge

University of South Australia

Paul Joyce

Chalmers, Fysik, Biologisk fysik

Expert Opinion on Drug Delivery

1742-5247 (ISSN)

Vol. 16 5 507-524


Farmaceutisk vetenskap





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