The Association of Red Meat Intake with Inflammation and Circulating Intermediate Biomarkers of Type 2 Diabetes Is Mediated by Central Adiposity
Artikel i vetenskaplig tidskrift, 2019

© The Author(s) 2019. We explored the role of lipid accumulation products and visceral adiposity on the association between red meat consumption and markers of insulin resistance (IR) and inflammation in US adults. Data on red meat consumption, and health outcome measurements were extracted from the 2005-2010 US National Health and Nutrition Examination Surveys. Overall 16,621 participants were included in the analysis (mean age = 47.1 years, 48.3% men). Analysis of co-variance and "conceptus causal mediation" models were applied, while accounting for survey design. In adjusted models, a lower red meat consumption was significantly associated with a cardio-protective profile of IR and inflammation. Body mass index (BMI) had significant mediation effects on the associations between red meat consumption and C-reactive protein (CRP), Apolipoprotein-B, fasting glucose (FBG), insulin, homeostatic model assessment (HOMA) IR and β-cell function, glycated haemoglobin (HbA1c), triglyceride to high density lipoprotein (TG:HDL) ratio and triglyceride-glucose (TyG) index (all p < 0.05). Both waist circumference and anthropometrically predicted visceral adipose tissue (apVAT) mediated the association between red meat consumption with CRP, FBG, HbA1c, TG: HDL ratio and TyG index (all p < 0.05). Our findings suggest that adiposity, particularly the accumulation of abdominal fat, accounts for a significant proportion of the associations between red meat consumption IR and inflammation.

Adiposity

Glucose Haemostasis

Inflammation

Meat Intake

Insulin Resistance

Författare

Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Andre Pascal Kengne

South African Medical Research Council

Elena S. George

Deakin University

Mario Siervo

University of Nottingham

British Journal of Nutrition

0007-1145 (ISSN) 1475-2662 (eISSN)

Ämneskategorier

Endokrinologi och diabetes

Annan klinisk medicin

Näringslära

DOI

10.1017/S0007114519002149

Mer information

Senast uppdaterat

2019-11-08