Global Incidence of Frailty and Prefrailty Among Community-Dwelling Older Adults A Systematic Review and Meta-analysis
Reviewartikel, 2019

IMPORTANCE
Frailty is a common geriatric syndrome of significant public health importance, yet there is limited understanding of the risk of frailty development at a population level.

OBJECTIVE

To estimate the global incidence of frailty and prefrailty among community-dwelling adults 60 years or older.

DATA SOURCES

MEDLINE, Embase, PsycINFO, Web of Science, CINAHL Plus, and AMED (Allied and Complementary Medicine Database) were searched from inception to January 2019 without language restrictions using combinations of the keywords frailty, older adults, and incidence. The reference lists of eligible studies were hand searched.

STUDY SELECTION
In the systematic review, 2 authors undertook the search, article screening, and study selection. Cohort studies that reported or had sufficient data to compute incidence of frailty or prefrailty among community-dwelling adults 60 years or older at baseline were eligible.

DATA EXTRACTION AND SYNTHESIS
The methodological quality of included studies was assessed using The Joanna Briggs Institute's Critical Appraisal Checklist for Prevalence and Incidence Studies. Meta-analysis was conducted using a random-effects (DerSimonian and Laird) model.

MAIN OUTCOMES AND MEASURES
Incidence of frailty (defined as new cases of frailty among robust or prefrail individuals) and incidence of prefrailty (defined as new cases of prefrailty among robust individuals), both over a specified duration.

RESULTS
Of 15 176 retrieved references, 46 observational studies involving 120 805 nonfrail (robust or prefrail) participants from 28 countries were included in this systematic review. Among the nonfrail individuals who survived a median follow-up of 3.0 (range, 1.0-11.7) years, 13.6%(13 678 of 100 313) became frail, with the pooled incidence rate being 43.4 (95% CI, 37.3-50.4; I-2 = 98.5%) cases per 1000 person-years. The incidence of frailty was significantly higher in prefrail individuals than robust individuals (pooled incidence rates, 62.7 [95% CI, 49.2-79.8; I-2 = 97.8%] vs 12.0 [95% CI, 8.2-17.5; I-2 = 94.9%] cases per 1000 person-years, respectively; P for difference < .001). Among robust individuals in 21 studies who survived a median follow-up of 2.5 (range, 1.0-10.0) years, 30.9% (9974 of 32 268) became prefrail, with the pooled incidence rate being 150.6 (95% CI, 123.3-184.1; I-2 = 98.9%) cases per 1000 person-years. The frailty and prefrailty incidence rates were significantly higher in women than men (frailty: 44.8 [95% CI, 36.7-61.3; I-2 = 97.9%] vs 24.3 [95% CI, 19.6-30.1; I-2 = 8.94%] cases per 1000 person-years; prefrailty: 173.2 [95% CI, 87.9-341.2; I-2 = 99.1%] vs 129.0 [95% CI, 73.8-225.0; I-2 = 98.5%] cases per 1000 person-years). The incidence rates varied by diagnostic criteria and country income level. The frailty and prefrailty incidence rates were significantly reduced when accounting for the risk of death.

CONCLUSIONS AND RELEVANCE
Results of this study suggest that community-dwelling older adults are prone to developing frailty. Increased awareness of the factors that confer high risk of frailty in this population subgroup is vital to inform the design of interventions to prevent frailty and to minimize its consequences.

Författare

Richard Ofori-Asenso

Monash University

Ken L. Chin

Monash University

University of Melbourne

Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Ella Zomer

Monash University

Jenni Ilomaki

Monash University

Andrew R. Zullo

Providence Veterans Affairs Medical Center

Brown University

Danijela Gasevic

University of Edinburgh

Monash University

Zanfina Ademi

Monash University

Maarit J. Korhonen

Monash University

Turun Yliopisto

Dina LoGiudice

Royal Melbourne Hosp

University of Melbourne

J. Simon Bell

University of Adelaide

Monash University

Danny Liew

Monash University

JAMA NETWORK OPEN

2574-3805 (ISSN)

Vol. 2 8 e198398

Ämneskategorier

Geriatrik

Gerontologi, medicinsk/hälsovetenskaplig inriktning

Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

DOI

10.1001/jamanetworkopen.2019.8398

PubMed

31373653

Mer information

Senast uppdaterat

2019-10-22