Solidification to improve the biopharmaceutical performance of SEDDS: Opportunities and challenges
Reviewartikel, 2019

Self-emulsifying drug delivery systems (SEDDS) offer potential for overcoming the inherent slow dissolution and poor oral absorption of hydrophobic drugs by retaining them in a solubilised state during gastrointestinal transit. However, the promising biopharmaceutical benefits of liquid lipid formulations has not translated into widespread commercial success, due to their susceptibility to long term storage and in vivo precipitation issues. One strategy that has emerged to overcome such limitations, is to combine the solubilisation and dissolution enhancing properties of lipids with the stabilising effects of solid carrier materials. The development of intelligent hybrid drug formulations has presented new opportunities to harness the potential of emulsified lipids in optimising oral bioavailability for lipophilic therapeutics. Specific emphasis of this review is placed on the impact of solidification approaches and excipients on the biopharmaceutical performance of self-emulsifying lipids, with findings highlighting the key design considerations that should be implemented when developing hybrid lipid-based formulations.

Lipid-based drug delivery system

Lipid-based formulation

Bioavailability

Oral delivery

Self-emulsifying lipids

SEDDS

Pharmacokinetics

Poorly water-soluble drugs

Solidification

Författare

Paul Joyce

Chalmers, Fysik, Biologisk fysik

Tahnee J. Dening

University of South Australia

Tahlia R. Meola

University of South Australia

Hayley B. Schultz

University of South Australia

René Holm

Roskilde University

Johnson&Johnson

Nicky Thomas

University of South Australia

Clive A. Prestidge

University of South Australia

Advanced Drug Delivery Reviews

0169-409X (ISSN)

Vol. 142 102-117

Ämneskategorier

Farmaceutisk vetenskap

Övrig annan teknik

Miljöledning

DOI

10.1016/j.addr.2018.11.006

PubMed

30529138

Mer information

Senast uppdaterat

2019-11-19