Circulating neurofilament light in ischemic stroke: temporal profile and outcome prediction
Artikel i vetenskaplig tidskrift, 2019

Background and purpose: Neurofilament light chain (NfL) is a marker of neuroaxonal damage. We aimed to study associations between serum NfL (sNfL) concentrations at different time points after ischemic stroke and outcomes. Methods: We prospectively included ischemic stroke cases (n = 595, mean age 59 years, 64% males) and assessed outcomes by both the modified Rankin Scale (mRS) and the NIH stroke scale (NIHSS) at 3 months and by mRS at 2 years. In a subsample, long-term (7-year) outcomes were also assessed by both mRS and NIHSS. We used the ultrasensitive single-molecule array assay to measure sNfL in the acute phase (range 1–14, median 4 days), after 3 months and 7 years in cases and once in controls (n = 595). Results: Acute-phase sNfL increased by the time to blood-draw and highest concentrations were observed at 3 months post-stroke. High sNfL associated to stroke severity and poor outcomes, and both associations were strongest for 3-month sNfL. After adjusting for age, previous stroke, stroke severity, and day of blood draw, 3-month sNfL was significantly associated to both outcomes at all time points (p < 0.01 throughout). For all main etiological subtypes, both acute phase and 3-month sNfL were significantly higher than in controls, but the dynamics of sNfL differed by stroke subtype. Conclusions: The results from this study inform on sNfL in ischemic stroke and subtypes over time, and show that sNfL predicts short- and long-term neurological and functional outcomes. Our findings suggest a potential utility of sNfL in ischemic stroke outcome prediction.

Prognosis

Biomarkers

Cerebrovascular disease

Stroke in young adults

Författare

Annie Pedersen

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Tara M. Stanne

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik

Göteborgs universitet

Sofia Klasson

Göteborgs universitet

Lars Rosengren

Göteborgs universitet

Lukas Holmegaard

Göteborgs universitet

Katarina Jood

Göteborgs universitet

Kaj Blennow

Sahlgrenska universitetssjukhuset

Göteborgs universitet

Henrik Zetterberg

University College London (UCL)

UCL Institute of Neurology

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Christina Jern

Göteborgs universitet

Sahlgrenska universitetssjukhuset

Journal of Neurology

0340-5354 (ISSN)

Vol. 266 11 2796-2806

Ämneskategorier

Neurologi

DOI

10.1007/s00415-019-09477-9

PubMed

31375988

Mer information

Senast uppdaterat

2019-11-22