Antibacterial effect of boron nitride flakes with controlled orientation in polymer composites
Artikel i vetenskaplig tidskrift, 2019

Boron nitride (BN) is a stable 2D material with physiochemical properties similar to graphene-based nanomaterials. We have recently demonstrated that vertically aligned coatings of graphene-based nanomaterials provide strong antibacterial effects on various surfaces. Here we investigated whether BN, a nanomaterial with extensive similarities to graphene, might exhibit similar antibacterial properties. To test this, we developed a novel composite material using BN and low density polyethylene (LDPE) polymer. The composite was extruded under controlled melt flow conditions leading to highly structured morphology, with BN oriented in the extrusion flow direction. Nanocomposite extruded surfaces perpendicular to the flow direction were etched, thus exposing BN nanoparticles embedded in the matrix. The antimicrobial activity of extruded samples was evaluated against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis and Staphylococcus aureus by the colony forming units (CFUs) counting method. Furthermore, the bactericidal effect of oriented BN against E. coli and S. aureus was evaluated by scanning electron microscopy (SEM) and live/dead viability assay. Our results suggest that BN nanoflakes on the extruded BN/LDPE composite physically interact with the bacterial cellular envelope, leading to irreparable physical damage. Therefore, we propose that BN–polymer composites might be useful to develop polymer based biomedical devices protected against bacterial adhesion, and thus minimize device associated infections.

Författare

Santosh Pandit

Chalmers, Biologi och bioteknik, Systembiologi

Karolina Gaska

Chalmers, Industri- och materialvetenskap, Konstruktionsmaterial

Venkata Raghavendra Subrahmanya Sar Mokkapati

Chalmers, Biologi och bioteknik, Systembiologi

Sven Forsberg

2D fab AB

Magnus Svensson

Wellspect Healthcare

Roland Kádár

Chalmers, Industri- och materialvetenskap, Konstruktionsmaterial

Ivan Mijakovic

Chalmers, Biologi och bioteknik, Systembiologi

Danmarks Tekniske Universitet (DTU)

RSC Advances

2046-2069 (ISSN)

Vol. 9 57 33454-33459

Styrkeområden

Nanovetenskap och nanoteknik (2010-2017)

Livsvetenskaper och teknik (2010-2018)

Materialvetenskap

Ämneskategorier

Annan biologi

Medicinska material och protesteknik

Kompositmaterial och -teknik

DOI

10.1039/c9ra06773f

Mer information

Senast uppdaterat

2019-12-05