Impact of serum 25-hydroxyvitamin D 25(OH) on telomere attrition: A Mendelian Randomization study
Artikel i vetenskaplig tidskrift, 2020

Background: Conventional observational studies have suggested that 25-hydroxyvitamin D (25(OH)D) is inversely associated with telomere shortening. We aimed to apply two-sample Mendelian randomization (MR) to assess the causal association between serum 25(OH) D and telomere length (TL). Methods: MR was implemented by using summary-level data from the largest genome-wide association studies (GWAS) on vitamin D (n = 73 699) and TL (n = 37 684). Inverse variance weighted method (IVW) was used to estimate the causal estimates. Weighted median (WM)-based method, and MR-Egger, leave-one-out were applied as sensitivity analysis. Results: The results of MR demonstrated no effect of 25(OH)D on TL (IVW = β:-0.104, p = 0.219, WM = β:-0.109, p = 0.188; MR Egger = β:-0.127, p = 0.506). None of the 25(OH)D-related single nucleotide polymorphisms (SNPs) were significantly associated with TL. Heterogeneity tests did not detect heterogeneity. Furthermore, MR pleiotropy residual sum and outlier (MR-PRESSO) did not highlight any outliers (p = 0.424). Results of leave-one-out method demonstrated that the links are not driven because of the single SNPs. Conclusions: Our study does not support any causal effect of 25(OH) D on TL.

25(OH)D

Telomere length

Mendelian randomization

Aging

25-Hydroxyvitamin D

Författare

Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Dimitri P. Mikhailidis

UCL Medical School

Maciej Banach

Uniwersytet Zielonogorski

Medical University of Lodz

Instytut Centrum Zdrowia Matki Polki

Abbas Dehghan

Imperial College London

Clinical Nutrition

0261-5614 (ISSN)

Vol. In press

Ämneskategorier

Endokrinologi och diabetes

Miljömedicin och yrkesmedicin

Näringslära

DOI

10.1016/j.clnu.2019.12.008

Mer information

Senast uppdaterat

2020-01-13