Injection moulded controlled release amorphous solid dispersions: Synchronized drug and polymer release for robust performance
Artikel i vetenskaplig tidskrift, 2020

A study has been carried out to investigate controlled release performance of caplet shaped injection moulded (IM) amorphous solid dispersion (ASD) tablets based on the model drug AZD0837 and polyethylene oxide (PEO). The physical/chemical storage stability and release robustness of the IM tablets were characterized and compared to that of conventional extended release (ER) hydrophilic matrix tablets of the same raw materials and compositions manufactured via direct compression (DC). To gain an improved understanding of the release mechanisms, the dissolution of both the polymer and the drug were studied. Under conditions where the amount of dissolution media was limited, the controlled release ASD IM tablets demonstrated complete and synchronized release of both PEO and AZD0837 whereas the release of AZD0837 was found to be slower and incomplete from conventional direct compressed ER hydrophilic matrix tablets. The results clearly indicated that AZD0837 remained amorphous throughout the dissolution process and was maintained in a supersaturated state and hence kept stable with the aid of the polymeric carrier when released in a synchronized manner. In addition, it was found that the IM tablets were robust to variation in hydrodynamics of the dissolution environment and PEO molecular weight.

Amorphous solid dispersion (ASD)

Release robustness

Injection moulding (IM)

Controlled release

Polymer release

Polyethylene oxide (PEO)

Poorly soluble drug

Oral solid dosage (OSD)

Hot melt extrusion (HME)

Författare

Shivprasad Deshmukh

AstraZeneca AB

University of Bradford

Anant Paradkar

University of Bradford

Susanna Abrahmsén-Alami

AstraZeneca AB

Rydvikha Govender

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Anette Larsson Group

AstraZeneca AB

Anna Viridén

AstraZeneca AB

Fredrik Winge

AstraZeneca AB

Hanna Matic

AstraZeneca AB

Jonathan Booth

AstraZeneca AB

Adrian Kelly

University of Bradford

International Journal of Pharmaceutics

0378-5173 (ISSN)

Vol. 575 118908

Ämneskategorier

Polymerkemi

Annan kemi

Medicinska material och protesteknik

DOI

10.1016/j.ijpharm.2019.118908

PubMed

31809859

Mer information

Senast uppdaterat

2020-04-06