Ultrasound-assisted synthesis of organotin compounds and their application as luminescent dye in silk fibroin scaffolds
Artikel i vetenskaplig tidskrift, 2020

In this work, we report the green synthesis of four luminescent organotin compounds 1–4 derived from amino acid Schiff bases (1: Naph-Trp-SnPh2, 2: Naph-Tyr-SnBu2, 3: Naph-Tyr-SnPh2, 4: Naph-Phe-SnPh2), obtained by ultrasound-assisted synthesis in short time (~20 min) and good yields (>95%). The molecular structure proposed in solution (1H and 119Sn NMR) was confirmed by X-ray diffraction study for compound 1 where the tin atom resides in trigonal bipyramid geometry. Luminescent silk fibroin scaffolds (SF 1–4) were elaborated with organotin compounds by freeze-drying technique. Photophysical properties of organotin compounds and scaffolds were obtained in solid state, observing bathochromic behaviors in tyrosine derived compounds, suggesting that the tyrosine produce supramolecular interactions across the –OH group that change the fluorescent properties. Scaffolds 1–4 were characterized by FTIR, XDR, TG/DTG, and SEM analysis. In addition, cytotoxic analysis of SF 1 presents high cellular viability, which could be applied as a scaffold in tissue engineering.

Organotin

Scaffold silk fibroin

X-ray

Ultrasound-assisted synthesis

Fluorescence

Författare

Jesús A. Lara-Cerón

Universidad Autonoma de Nuevo Leon

Víctor M. Jiménez-Pérez

Universidad Autonoma de Nuevo Leon

Areli A. Molina-Paredes

Universidad Autonoma de Nuevo Leon

María E. Ochoa

Centro de Investigacion y de Estudios Avanzados (CINVESTAV)

Rafael M. Sábio

Laboratory of Polymers and Biomaterials University of Araraquara (UNIARA)

São Carlos Institute of Physics – University of São Paulo (USP)

André C. Amaral

Laboratory of Polymers and Biomaterials University of Araraquara (UNIARA)

Robson Rosa Da Silva

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Kasper Moth-Poulsen Group

Sidney J.L. Ribeiro

Universidade Estadual Paulista (UNESP)

Hernane da S. Barud

Laboratory of Polymers and Biomaterials University of Araraquara (UNIARA)

Víctor M. Jiménez-Pérez

Universidad Autonoma de Nuevo Leon

Inorganica Chimica Acta

0020-1693 (ISSN)

Vol. 505 119490

Ämneskategorier

Oorganisk kemi

Materialkemi

Organisk kemi

DOI

10.1016/j.ica.2020.119490

Mer information

Senast uppdaterat

2020-02-17