Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment
Artikel i vetenskaplig tidskrift, 2020

Cognitive decline is one of the complications of type 2 diabetes (T2D). Intermittent fasting (IF) is a promising dietary intervention for alleviating T2D symptoms, but its protective effect on diabetes-driven cognitive dysfunction remains elusive. Here, we find that a 28-day IF regimen for diabetic mice improves behavioral impairment via a microbiota-metabolites-brain axis: IF enhances mitochondrial biogenesis and energy metabolism gene expression in hippocampus, re-structures the gut microbiota, and improves microbial metabolites that are related to cognitive function. Moreover, strong connections are observed between IF affected genes, microbiota and metabolites, as assessed by integrative modelling. Removing gut microbiota with antibiotics partly abolishes the neuroprotective effects of IF. Administration of 3-indolepropionic acid, serotonin, short chain fatty acids or tauroursodeoxycholic acid shows a similar effect to IF in terms of improving cognitive function. Together, our study purports the microbiota-metabolites-brain axis as a mechanism that can enable therapeutic strategies against metabolism-implicated cognitive pathophysiologies.

Författare

Zhigang Liu

Northwest A&F university

Xiaoshuang Dai

BGI Institute of Applied Agriculture

Hongbo Zhang

Northwest A&F university

Renjie Shi

Northwest A&F university

Yan Hui

BGI Institute of Applied Agriculture

Köpenhamns universitet

Xin Jin

BGI Institute of Applied Agriculture

Wentong Zhang

Northwest A&F university

Luanfeng Wang

Northwest A&F university

Qianxu Wang

Northwest A&F university

Danna Wang

Northwest A&F university

Jia Wang

Northwest A&F university

Xintong Tan

Northwest A&F university

Bo Ren

Northwest A&F university

Xiaoning Liu

Northwest A&F university

Tong Zhao

Northwest A&F university

Jiamin Wang

Northwest A&F university

Junru Pan

Northwest A&F university

Tian Yuan

Northwest A&F university

Chuanqi Chu

Northwest A&F university

Lei Lan

BGI Institute of Applied Agriculture

Fei Yin

University of Arizona

Enrique Cadenas

University of Southern California

Lin Shi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Shancen Zhao

BGI Institute of Applied Agriculture

Xuebo Liu

Northwest A&F university

Nature Communications

2041-1723 (ISSN)

Vol. 11 1 855- 855

Ämneskategorier

Endokrinologi och diabetes

Annan klinisk medicin

Neurovetenskaper

DOI

10.1038/s41467-020-14676-4

PubMed

32071312

Mer information

Senast uppdaterat

2020-04-16