Ruthenium-Catalyzed E-Selective Alkyne Semihydrogenation with Alcohols as Hydrogen Donors
Artikel i vetenskaplig tidskrift, 2020

Selective direct ruthenium-catalyzed semihydrogenation of diaryl alkynes to the corresponding E-alkenes has been achieved using alcohols as the hydrogen source. The method employs a simple ruthenium catalyst, does not require external ligands, and affords the desired products in > 99% NMR yield in most cases (up to 93% isolated yield). Best results were obtained using benzyl alcohol as the hydrogen donor, although biorenewable alcohols such as furfuryl alcohol could also be applied. In addition, tandem semihydrogenation-alkylation reactions were demonstrated, with potential applications in the synthesis of resveratrol derivatives.

Författare

Andreas Ekebergh

Chalmers, Kemi och kemiteknik, Kemi och biokemi

Romain Bordes

Chalmers, Kemi och kemiteknik, Tillämpad kemi

Nina Kann

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Journal of Organic Chemistry

0022-3263 (ISSN) 1520-6904 (eISSN)

Vol. 85 5 2966-2975

Ämneskategorier

Kemiska processer

Biokatalys och enzymteknik

Organisk kemi

DOI

10.1021/acs.joc.9b02721

PubMed

32027128

Mer information

Senast uppdaterat

2020-03-12