IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections
Artikel i vetenskaplig tidskrift, 2019
Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are predictive of resolution of hepatitis C virus infection, but information about the impact of these variants in other infections is scarce. This study aimed at determining the potential impact of IFNL4 variation for the clearance of respiratory tract pathogens in Rwandan children (<= 5 years old, n = 480) seeking medical care for acute respiratory infections. Nasopharyngeal swabs were retrieved from all children at the first hospital referral and from 161 children at follow-up visits 2 weeks later. The swabs were analyzed for pathogens by real-time PCR and for host cell IFNL4 genotype at rs12979860 and rs368234815. Approximately 1/3 of the children were homozygous for the rs12979860 T allele and the rs368234815 Delta G allele, which are overrepresented in subjects of African descent. These IFNL4 variants were significantly associated with reduced clearance of RNA viruses. Our results suggest that IFNL4 genotypes that are common among subjects of African descent may determine inefficacious clearance of RNA viruses from the respiratory tract.
upper respiratory tract
single nucleotide polymorphisms
dinucleotide polymorphisms
infection
rs368234815
rs12979860
RNA virus
interferon lambda
Författare
Belson Rugwizangoga
Göteborgs universitet
University of Rwanda
Maria E. Andersson
Göteborgs universitet
Jean-Claude Kabayiza
Göteborgs universitet
University of Rwanda
Malin S. Nilsson
Göteborgs universitet
Brynja Armannsdottir
Göteborgs universitet
Johan Aurelius
Göteborgs universitet
Staffan Nilsson
Chalmers, Matematiska vetenskaper, Tillämpad matematik och statistik
Göteborgs universitet
Kristoffer Hellstrand
Göteborgs universitet
Magnus Lindh
Göteborgs universitet
Anna Martner
Göteborgs universitet
Frontiers in cellular and infection microbiology
2235-2988 (ISSN)
Vol. 9 340Ämneskategorier
Pediatrik
Infektionsmedicin
Mikrobiologi inom det medicinska området
DOI
10.3389/fcimb.2019.00340
PubMed
31637221