Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting
Artikel i vetenskaplig tidskrift, 2020

Glutamine is a central nutrient for many cancers, contributing to the generation of building blocks and energy-promoting signaling necessary for neoplastic proliferation. In this study, we hypothesized that lowering systemic glutamine levels by exercise may starve tumors, thereby contributing to the inhibitory effect of exercise on tumor growth. We demonstrate that limiting glutamine availability, either pharmacologically or physiologically by voluntary wheel running, significantly attenuated the growth of two syngeneic murine tumor models of breast cancer and lung cancer, respectively, and decreased markers of atrophic signaling in muscles from tumor-bearing mice. In continuation, wheel running completely abolished tumor-induced loss of weight and lean body mass, independently of the effect of wheel running on tumor growth. Moreover, wheel running abolished tumor-induced upregulation of muscular glutamine transporters and myostatin signaling. In conclusion, our data suggest that voluntary wheel running preserves muscle mass by counteracting muscular glutamine release and tumor-induced atrophic signaling.

Physiology

Cancer

Specialized Functions of Cells

Författare

K. S. Pedersen

Copenhagen University Hospital

Francesco Gatto

Elypta AB

Chalmers, Biologi och bioteknik, Systembiologi

Bo Zerahn

Amtssygehuset i Herlev

Jens B Nielsen

Chalmers, Biologi och bioteknik, Systembiologi

B. K. Pedersen

Copenhagen University Hospital

P. Hojman

Copenhagen University Hospital

J. Gehl

Sjællands Universitetshospital

Köpenhamns universitet

iScience

25890042 (eISSN)

Vol. 23 4 100978

Ämneskategorier

Fysiologi

Radiologi och bildbehandling

Cancer och onkologi

DOI

10.1016/j.isci.2020.100978

Mer information

Senast uppdaterat

2020-05-25