Systematic review with meta-analysis: Effects of probiotic supplementation on symptoms in functional dyspepsia
Reviewartikel, 2020

The pathophysiology of functional dyspepsia (FD) remains poorly understood, but alterations of the small intestinal microbiome have been observed. The place of probiotics in treatment is uncertain. We performed a systematic review and meta-analysis of the currently available randomized, controlled trials (RCTs) to evaluate the potential beneficial effects and risks of probiotics in FD. Pubmed, EMBASE, Scopus, Web of Science and the Cochrane Controlled Trials Register were searched (up to May 2019) for RCTs evaluating the effects of probiotic supplementation compared to placebo in adults with FD. Two reviewers independently assessed eligibility, trial quality and extracted information from identified articles. To compare the effects of probiotics with placebo, risk ratios (RRs) with 95% confidence intervals (CIs) were pooled using random effects models. Six trials, including 422 participants were included but only three RCTs could be included in the meta-analysis. Lactobacillus strains showed potential positive effects in terms of improving upper gastrointestinal (GI) symptoms in patients with FD. Probiotic supplementation tended to improve global dyspepsia score (n = 3 RCTs, risk ratio [RR]: 1.35, 95% CI 0.99 to 1.84; P = 0.061) and bacterial composition in the GI tract. Probiotics were well tolerated without any serious adverse events. While the available data suggest that supplementation with probiotics may improve GI symptoms in patients with FD, the evidence is insufficient to draw clear conclusions regarding efficacy. Thus, high-quality RCTs are needed to establish the beneficial effects of probiotic supplementation on FD outcomes.

Functional dyspepsia




Shahram Agah

University of Adelaide

Iran University of Medical Sciences

Abolfazl Akbari

Iran University of Medical Sciences

Javad Heshmati

Kermanshah University of Medical Sciences

Mahdi Sepidarkish

Babol University of Medical Sciences

Mojgan Morvaridzadeh

Kermanshah University of Medical Sciences

Payman Adibi

Isfahan University of Medical Sciences

Mohsen Mazidi

Chalmers, Biologi och bioteknik, Livsmedelsvetenskap

Farnaz Farsi

Iran University of Medical Sciences

Richard Ofori-Asenso

Monash University

Nicholas J. Talley

University of Newcastle

Christine Feinle-Bisset

University of Adelaide

Journal of Functional Foods

1756-4646 (ISSN)

Vol. 68 103902



Urologi och njurmedicin




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