Enhanced distribution kinetics in liquid-liquid extraction byCO2-expanded solvents
Artikel i vetenskaplig tidskrift, 2020

Liquid-liquid extraction (LLE) is a useful extraction technique for highly complex samples, however, itsuffers from being slow due to mass transfer limitations. Carbon dioxide expanded liquids (CXL) is a goodreplacement of traditional organic solvents for extraction, and for the first time, the use of CXL in LLEwas evaluated. An equipment consisting of a high-pressure view cell with on-line gas chromatographyanalysis was built and validated, and thereafter used to obtain novel phase equilibria data of the CO2/n-octanol/water system. The system was connected on-line to HPLC to study the potential of CO2-expandedliquid-liquid extraction (CXLLE) of pharmaceutical contaminants in water. In comparison with tradi-tional LLE performed under similar experimental conditions, the addition of CO2as a viscosity-loweringentrainer significantly increased the speed of mass transfer. Changes in compound log D (octanol-waterdistribution ratio) values brought by the CO2expansion also proved the possibility of selectivity-tuningin CXLLE.


Larissa P. Cunico

Lunds universitet

Mingzhe Sun

Lunds universitet

Yu Rui

Lunds universitet

Semhar Ghirmai

Lunds universitet

Markus Enekvist

Lunds universitet

Simon Lundegard

Lunds universitet

Margareta Sandahl

Lunds universitet

Charlotta Turner

Lunds universitet

Journal of Supercritical Fluids

0896-8446 (ISSN)


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