Enhanced distribution kinetics in liquid-liquid extraction byCO2-expanded solvents
Artikel i vetenskaplig tidskrift, 2020

Liquid-liquid extraction (LLE) is a useful extraction technique for highly complex samples, however, it suffers from being slow due to mass transfer limitations. Carbon dioxide expanded liquids (CXL) is a good replacement of traditional organic solvents for extraction, and for the first time, the use of CXL in LLE was evaluated. An equipment consisting of a high-pressure view cell with on-line gas chromatography analysis was built and validated, and thereafter used to obtain novel phase equilibria data of the CO2/n-octanol/water system. The system was connected on-line to HPLC to study the potential of CO2-expanded liquid-liquid extraction (CXLLE) of pharmaceutical contaminants in water. In comparison with traditional LLE performed under similar experimental conditions, the addition of CO2 as a viscosity-lowering entrainer significantly increased the speed of mass transfer. Changes in compound log D (octanol-water distribution ratio) values brought by the CO2 expansion also proved the possibility of selectivity-tuning in CXLLE.


Larissa P. Cunico

Lunds universitet

Mingzhe Sun

Lunds universitet

Yu Rui

Lunds universitet

Semhar Ghirmai

Lunds universitet

Markus Enekvist

Lunds universitet

Simon Lundegard

Lunds universitet

Margareta Sandahl

Lunds universitet

Charlotta Turner

Lunds universitet

Journal of Supercritical Fluids

0896-8446 (ISSN)


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